Convenient synthesis and characterization of new 1,3,4-thiadiazoles and thiazoles incorporating thiophene moiety

被引：0

作者：

Helmy, Mirna T. ^{[1
]}

Kamel, Monica G. ^{[1
]}

Mikhail, Madonna S. ^{[1
]}

Saleh, Fatma M. ^{[1
]}

Hassaneen, Hamdi M. ^{[1
]}

Erian, Ayman W. ^{[1
]}

Teleb, Mohamed A. Mohamed ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt

来源：

ARKIVOC | 2024年

关键词：

1; 3; 4-Thiadiazoles; pyrazole; methyl hydrazinecarbodithioate; thiazoles; cycloaddition reaction; HYDRAZONOYL HALIDES; ANTIPROLIFERATIVE ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTICANCER; CHEMISTRY; BROMIDE; REGIOSELECTIVITY; PYRAZOLINES; NITROGEN;

D O I：

10.24820/ark.5550190.p012.207

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of substituted acetylpyrazole with methyl hydrazinecarbodithioate using hydrochloric acid as a catalyst in absolute ethanol afforded methyl 2-(1-(1H-pyrazol-4-yl)ethylidene)hydrazinecarbodithioate H-pyrazol-4-yl)ethylidene)hydrazinecarbodithioate derivative. Refluxing of the latter product with hydrazonoyl halides in absolute ethanol in the presence of triethylamine afforded the corresponding 1,3,4-thiadiazoles. Heating the same acetylpyrazole with hydrazinecarbothioamide in refluxing ethanol using hydrochloric acid as a catalyst afforded 2-(1-(1H-pyrazol-4- H-pyrazol-4- yl)ethylidene)hydrazinecarbothioamide derivative. The reaction of the latter compound with omega- bromoacetophenone derivatives in absolute ethanol at reflux afforded the corresponding thiazole derivatives.

引用

页数：12

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