Ubiquitination and De-Ubiquitination in the Synthesis of Cow Milk Fat: Reality and Prospects

被引:0
|
作者
Gao, Rui [1 ]
Wu, Yanni [1 ]
Wang, Yuhao [1 ]
Yang, Zhangping [1 ]
Mao, Yongjiang [1 ]
Yang, Yi [1 ]
Yang, Chunhua [2 ]
Chen, Zhi [1 ]
机构
[1] Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China
[2] Jiangxi Acad Sci, Inst Biol Resources, Nanchang 330029, Peoples R China
来源
MOLECULES | 2024年 / 29卷 / 17期
基金
中国国家自然科学基金;
关键词
ubiquitination; de-ubiquitination; proteasome; fatty acids; milk fat; MAMMARY EPITHELIAL-CELLS; ELEMENT-BINDING PROTEIN-1; ACTIVATED RECEPTOR-GAMMA; DEPENDENT DEGRADATION; FASN GENE; ACID; EXPRESSION; MECHANISM; ENZYME; UBIQUITYLATION;
D O I
10.3390/molecules29174093
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ubiquitination modifications permit the degradation of labelled target proteins with the assistance of proteasomes and lysosomes, which is the main protein degradation pathway in eukaryotic cells. Polyubiquitination modifications of proteins can also affect their functions. De-ubiquitinating enzymes reverse the process of ubiquitination via cleavage of the ubiquitin molecule, which is known as a de-ubiquitination. It was demonstrated that ubiquitination and de-ubiquitination play key regulatory roles in fatty acid transport, de novo synthesis, and desaturation in dairy mammary epithelial cells. In addition, natural plant extracts, such as stigmasterol, promote milk fat synthesis in epithelial cells via the ubiquitination pathway. This paper reviews the current research on ubiquitination and de-ubiquitination in dairy milk fat production, with a view to providing a reference for subsequent research on milk fat and exploring new directions for the improvement of milk quality.
引用
收藏
页数:18
相关论文
共 50 条
  • [41] Stigmasterol Activates the mTOR Signaling Pathway by Inhibiting ORP5 Ubiquitination to Promote Milk Synthesis in Bovine Mammary Epithelial Cells
    Sun, Mingyang
    Cao, Yu
    Cheng, Ji
    Xu, Dianwen
    Li, Feng
    Wang, Jiaxin
    Ge, Yusong
    Liu, Yuhao
    Long, Xiaoyu
    Guo, Wenjin
    Liu, Juxiong
    Fu, Shoupeng
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 72 (26) : 14769 - 14785
  • [42] Suppression of cGAS-STING- and RIG-I-MAVS-mediated innate immune responses by Epstein-Barr virus-encoded tegument protein BPLF1 through de-ubiquitination
    Lui, Wai Yin
    Yuen, Kit-San
    Jin, Dong-Yan
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
  • [43] Proteasome 26S subunit, non-ATPase 1 (PSMD1) facilitated the progression of lung adenocarcinoma by the de-ubiquitination and stability of PTEN-induced kinase 1 (PINK1)
    Liu, Lihua
    Liu, Aihua
    Dong, Jun
    Zuo, Zhongfu
    Liu, Xuezheng
    EXPERIMENTAL CELL RESEARCH, 2022, 413 (02)
  • [44] Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells
    Lili Liu
    Ye Lin
    Lixin Liu
    Lina Wang
    Yanjie Bian
    Xuejun Gao
    Qingzhang Li
    In Vitro Cellular & Developmental Biology - Animal, 2016, 52 : 1044 - 1059
  • [45] The functions and mechanisms of sequence differences of DGAT1 gene on milk fat synthesis between dairy cow and buffalo
    Bhattarai, Dinesh
    Dad, Rahim
    Worku, Tesfay
    Xul, Sutong
    Ullah, Farman
    Zhang, Min
    Liang, Xianwei
    Den, Tingxian
    Fan, Mingxia
    Zhang, Shujun
    JOURNAL OF DAIRY RESEARCH, 2020, 87 (02) : 170 - 174
  • [46] Functional analysis of FABP3 in the milk fat synthesis signaling pathway of dairy cow mammary epithelial cells
    Meng-yao Liang
    Xiao-ming Hou
    Bo Qu
    Na Zhang
    Nan Li
    Ying-jun Cui
    Qing-zhang Li
    Xue-jun Gao
    In Vitro Cellular & Developmental Biology - Animal, 2014, 50 : 865 - 873
  • [47] Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells
    Liu, Lili
    Lin, Ye
    Liu, Lixin
    Wang, Lina
    Bian, Yanjie
    Gao, Xuejun
    Li, Qingzhang
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2016, 52 (10) : 1044 - 1059
  • [48] Functional analysis of FABP3 in the milk fat synthesis signaling pathway of dairy cow mammary epithelial cells
    Liang, Meng-yao
    Hou, Xiao-ming
    Qu, Bo
    Zhang, Na
    Li, Nan
    Cui, Ying-jun
    Li, Qing-zhang
    Gao, Xue-jun
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2014, 50 (09) : 865 - 873
  • [49] CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1
    Lei, Kai
    Liang, Ruihao
    Liang, Jialu
    Lu, Nan
    Huang, Jing
    Xu, Ke
    Tan, Binghua
    Wang, Kexi
    Liang, Yicheng
    Wang, Wenjian
    Lin, Huayue
    Wang, Minghui
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2024, 43 (01)
  • [50] Stigmasterol Activates the mTOR Signaling Pathway by Inhibiting ORP5 Ubiquitination to Promote Milk Synthesis in Bovine Mammary Epithelial Cells (vol 72, 26, 2024)
    Sun, Mingyang
    Cao, Yu
    Cheng, Ji
    Xu, Dianwen
    Li, Feng
    Wang, Jiaxin
    Ge, Yusong
    Liu, Yuhao
    Long, Xiaoyu
    Guo, Wenjin
    Liu, Juxiong
    Fu, Shoupeng
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 73 (04) : 2715 - 2716