Ubiquitination and De-Ubiquitination in the Synthesis of Cow Milk Fat: Reality and Prospects

被引:0
|
作者
Gao, Rui [1 ]
Wu, Yanni [1 ]
Wang, Yuhao [1 ]
Yang, Zhangping [1 ]
Mao, Yongjiang [1 ]
Yang, Yi [1 ]
Yang, Chunhua [2 ]
Chen, Zhi [1 ]
机构
[1] Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China
[2] Jiangxi Acad Sci, Inst Biol Resources, Nanchang 330029, Peoples R China
来源
MOLECULES | 2024年 / 29卷 / 17期
基金
中国国家自然科学基金;
关键词
ubiquitination; de-ubiquitination; proteasome; fatty acids; milk fat; MAMMARY EPITHELIAL-CELLS; ELEMENT-BINDING PROTEIN-1; ACTIVATED RECEPTOR-GAMMA; DEPENDENT DEGRADATION; FASN GENE; ACID; EXPRESSION; MECHANISM; ENZYME; UBIQUITYLATION;
D O I
10.3390/molecules29174093
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ubiquitination modifications permit the degradation of labelled target proteins with the assistance of proteasomes and lysosomes, which is the main protein degradation pathway in eukaryotic cells. Polyubiquitination modifications of proteins can also affect their functions. De-ubiquitinating enzymes reverse the process of ubiquitination via cleavage of the ubiquitin molecule, which is known as a de-ubiquitination. It was demonstrated that ubiquitination and de-ubiquitination play key regulatory roles in fatty acid transport, de novo synthesis, and desaturation in dairy mammary epithelial cells. In addition, natural plant extracts, such as stigmasterol, promote milk fat synthesis in epithelial cells via the ubiquitination pathway. This paper reviews the current research on ubiquitination and de-ubiquitination in dairy milk fat production, with a view to providing a reference for subsequent research on milk fat and exploring new directions for the improvement of milk quality.
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页数:18
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