Phenotyping sleep disturbances in ADHD and identifying harmonised outcome measures

被引:0
|
作者
Ipsiroglu, Osman S. [1 ,2 ,3 ,4 ]
Kloesch, Gerhard [4 ,5 ]
Stein, Mark [6 ]
Blunden, Sarah [7 ]
Brand, Serge [8 ,9 ,10 ,11 ,12 ]
Clemens, Stefan [13 ]
Cortese, Samuele [14 ,15 ,16 ,17 ,18 ]
Dueck, Alexander [19 ]
Dye, Thomas [20 ]
Gringras, Paul [21 ,22 ]
Kuehle, Hans-Juergen [22 ]
Lawrence, Kate [23 ]
Lecendreux, Michel [24 ]
Miano, Silvia [25 ]
Mollin, Julian [26 ]
Nobili, Lino [27 ]
Owens, Judy [28 ]
Kaur Pandher, Parveer [1 ,2 ]
Sadeghi-Bahmani, Dena [29 ,30 ]
Schlarb, Angelika Anita [31 ]
Schneider, Barbara [32 ]
Silvestri, Rosalia [33 ]
Smith, Susan [34 ]
Spruyt, Karen [35 ]
Weiss, Margaret Danielle [36 ]
机构
[1] Univ British Columbia, Dept Pediat, Interdisciplinary Sleep Program, Sleep Wake Behav Clin, Vancouver, BC, Canada
[2] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada
[3] Med Univ Vienna, Dept Pediat, Vienna, Austria
[4] Inst Sleep & Wake Res, Vienna, Austria
[5] Med Univ Vienna, Dept Neurol, Vienna, Austria
[6] Univ Washington, Seattle Childrens Hosp, ADHD & Related Disorders Program, Seattle, WA USA
[7] Monash Univ, Appleton Inst Behav Sci, CQUnivers Australia, Adelaide Campus, Melbourne, Australia
[8] Univ Basel, Ctr Affect Stress & Sleep Disorders ZASS, Psychiat Clin, Basel, Switzerland
[9] Univ Basel, Dept Sport Exercise & Hlth, Dept Med, Div Sport Sci & Psychosocial Hlth, Basel, Switzerland
[10] Kermanshah Univ Med Sci, Subst Abuse Prevent Res Ctr, Kermanshah, Iran
[11] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah, Iran
[12] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[13] East Carolina Univ, Dept Physiol, Greenville, NC USA
[14] Univ Southampton, Fac Environm & Life Sci, Ctr Innovat Mental Hlth, Sch Psychol, Southampton, England
[15] Univ Southampton, Fac Med, Clin & Expt Sci CNS & Psychiat, Southampton, England
[16] Solent NHS Trust, Southampton, England
[17] NYU, NYU Langone, Hassenfeld Childrens Hosp, Child Study Ctr, New York, NY USA
[18] Univ Bari Aldo Moro, DiMePRe J Dept Precis & Rigenerat Med Jon Area, Bari, Italy
[19] Univ Med Ctr, Dept Child & Adolescent Psychiat & Neurol, Rostock, Germany
[20] Univ Cincinnati, Dept Pediat, Div Neurol, Cincinnati, OH USA
[21] St Thomas Hosp, Kings Coll London, London, England
[22] St Thomas Hosp, Evelina Childrens Hosp, London, England
[23] St Marys Univ, Sch Allied Hlth & Life Sci, Psychol, London, England
[24] Univ Hosp Robert Debre, Paris, France
[25] Univ Svizzera Italiana, Osped Civico, Fac Biomed Sci, Sleep Med Unit, Lugano, Switzerland
[26] Klinikum Westbrandenburg, Potsdam, Germany
[27] Ist Giannina Gaslini, Child Neuropsychiat Unit, Genoa, Italy
[28] Childrens Hosp, Ctr Pediat Sleep Disorders, Dept Neurol, Sleep Med, Boston, MA USA
[29] Stanford Univ, Sch Med, Dept Psychol, Stanford, CA USA
[30] Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA USA
[31] Bielefeld Univ, Dept Psychol, Bielefeld, Germany
[32] St Marien gGmbH, Sozialpadiatr Zentrum Landshut Kinderkrankenhaus, Landshut, Germany
[33] Messina Univ, Sleep Med Ctr, Dept Clin & Expt Med, Neurophysiopathol & Movement Disorders Unit, Messina, Italy
[34] Univ N Carolina, UNC Nutr Res Inst, Chapel Hill, NC USA
[35] Univ Paris, NeuroDiderot, Paris, France
[36] Harvard Univ, Dept Child Psychiat, Cambridge, MA USA
来源
SOMNOLOGIE | 2024年 / 28卷 / 03期
关键词
Behavioural medicine; Restless legs syndrome; Periodic limb movements in sleep; Vigilance; Sleep disordered breathing; Verhaltensmedizin; Syndrom der unruhigen Beine; Periodische Bewegungen der Gliedma ss en im Schlaf und Wachzustand; Vigilanz; Schlafbezogene Atmungsst & ouml; rungen; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; RESTLESS LEGS SYNDROME; DIAGNOSTIC-CRITERIA; CHILDREN; DEFINITION; BEHAVIORS; VIGILANCE; UPDATE; IMPACT;
D O I
10.1007/s11818-024-00473-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Attention deficit hyperactivity disorder (ADHD) is a widespread neurodevelopmental disorder. Currently, the diagnosis and treatment of ADHD in children and adolescents is primarily centred on daytime functioning and the associated impairment of academic performance, although disrupted and restless sleep have been frequently reported in individuals with ADHD. Further, it has been recognised that sleep disorders not only intensify existing ADHD symptoms but in some cases can also mimic ADHD symptoms in the paediatric population with primary sleep disorders. Under the title 'The blind spot: sleep as a child's right issue?', professionals from diverse disciplines, including medicine and social sciences as well as individuals with an interest in ADHD and sleep medicine, including laypeople, have initiated a unifying discourse. The objective of this discourse is to improve our understanding of the diagnosis and treatment of ADHD and disruptive behaviours and to develop personalised and precision medicine. Research has shown that the existing, primarily descriptive and categorical diagnostic systems do not capture the heterogeneous nature of youth with attentional and behavioural difficulties and the phenotypic expressions thereof, including nighttime behaviours and sleep. New strategies for clinical phenotyping and the exploration of patient-reported behaviours are necessary to expand our understanding and develop personalised treatment approaches. In this position paper, we outline gaps in the clinical care of ADHD and related sleep disturbances, review strategies for closing these gaps to meet the needs of individuals with ADHD, and suggest a roadmap for escaping the one-size-fits-all approach that has characterised ADHD treatment algorithms to date. Die Aufmerksamkeitsdefizit-Hyperaktivit & auml;tsst & ouml;rung (ADHS) ist eine weit verbreitete Entwicklungsst & ouml;rung. Ihre Diagnose und Behandlung konzentrierte sich bisher weitgehend auf die Tagessymptomatik. Das Schlafverhalten blieb dabei weitgehend unber & uuml;cksichtigt, obwohl Betroffene immer wieder & uuml;ber Unruhe und nicht erholsamen Schlaf klagten. Allerdings wurde in Studien nachgewiesen, dass Schlafst & ouml;rungen, in Verbindung mit einem bestimmten Lebensstil, bestehende ADHS-Symptome nicht nur intensivieren, sondern auch bei Kindern mit prim & auml;ren Schlafst & ouml;rungen sogar ADHS-Symptome imitieren k & ouml;nnen. Unter dem Titel ,,Der blinde Fleck: Schlaf als Kinderrecht?" haben Fachleute aus unterschiedlichen Disziplinen von der Humanmedizin bis hin zu den Sozialwissenschaften sowie Personen mit Interesse an ADHS eine Diskussion initiiert, um die L & uuml;cken in unserem Verst & auml;ndnis von ADHS und deren Behandlung aufzuzeigen und im Sinne einer personalisierten Medizin zu schlie ss en. Es wurde gezeigt, dass die aktuellen kategorialen Diagnosen von Verhaltensst & ouml;rungen die enorme F & uuml;lle ph & auml;notypischer Auspr & auml;gungen nicht ber & uuml;cksichtigen, wodurch eine Beurteilung der diagnostischen Genauigkeit und die Wirksamkeit therapeutischer Ans & auml;tze erschwert werden. Um eine personalisierte Medizin bei der Diagnose und Therapie des ADHS zu gew & auml;hrleisten, sind neue Ans & auml;tze im Rahmen der klinischen Ph & auml;notypisierung und bei der Beurteilung des Patientenverhaltens dringend notwendig. In diesem Positionspapier werden die L & uuml;cken in der klinischen Versorgung von ADHS-Patienten dargestellt und auf die Notwendigkeit der Ber & uuml;cksichtigung von Schlafst & ouml;rungen hingewiesen, um in weiterer Folge Strategien zur Schlie ss ung der L & uuml;cken zwischen den Bed & uuml;rfnissen von Personen mit ADHS und den aktuellen Behandlungsans & auml;tzen aufzuzeigen.
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收藏
页码:189 / 200
页数:11
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