Modulation of Macrophage Polarization via Fluorescein Conjugation with Iron Oxide Nanoparticles for MR Imaging

被引：0

作者：

Soni, Raghav ^{[1
]}

Mahara, Atsushi ^{[1
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr Res Inst, Suita, Osaka 5648565, Japan

来源：

ACS APPLIED NANO MATERIALS | 2024年 / 7卷 / 19期

基金：

日本学术振兴会;

关键词：

iron oxide nanoparticles; fluorescein; macrophagepolarization; polyethylene glycol; MRI contrast;

D O I：

10.1021/acsanm.4c02947

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We reported the regulation of macrophage polarization by iron oxide nanoparticles through conjugation with fluorescein and polyethylene glycol. When the modified nanoparticles were taken up by macrophages, the M2 phenotype was induced by upregulating anti-inflammatory markers such as CD163 and CD209, as well as associated transcripts such as IL10 and TGF-beta, potentially for use as an MR contrast agent with minimal pro-inflammatory stimulation.

引用

页码：22417 / 22422

页数：6

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