Modulation of Macrophage Polarization via Fluorescein Conjugation with Iron Oxide Nanoparticles for MR Imaging

被引：0

作者：

Soni, Raghav ^{[1
]}

Mahara, Atsushi ^{[1
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr Res Inst, Suita, Osaka 5648565, Japan

来源：

ACS APPLIED NANO MATERIALS | 2024年 / 7卷 / 19期

基金：

日本学术振兴会;

关键词：

iron oxide nanoparticles; fluorescein; macrophagepolarization; polyethylene glycol; MRI contrast;

D O I：

10.1021/acsanm.4c02947

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We reported the regulation of macrophage polarization by iron oxide nanoparticles through conjugation with fluorescein and polyethylene glycol. When the modified nanoparticles were taken up by macrophages, the M2 phenotype was induced by upregulating anti-inflammatory markers such as CD163 and CD209, as well as associated transcripts such as IL10 and TGF-beta, potentially for use as an MR contrast agent with minimal pro-inflammatory stimulation.

引用

页码：22417 / 22422

页数：6

共 50 条

[31] Superparamagnetic Iron Oxide Nanoparticles Coated with Mannan for Macrophage Targeting
Yoo, Mi Kyong
Park, In Young
Kim, In Yong
Park, In Kyu
Kwon, Jin-Sook
Jeong, Hwan-Jeong
Jeong, Yong Yeon
Cho, Chong Su
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2008, 8 (10) : 5196 - 5202
[32] Modulation of Magnetic Heating via Dipolar Magnetic Interactions in Monodisperse and Crystalline Iron Oxide Nanoparticles
Salas, Gorka
Camarero, Julio
Cabrera, David
Takacs, Helene
Varela, Maria
Ludwig, Robert
Daehring, Heidi
Hilger, Ingrid
Miranda, Rodolfo
del Puerto Morales, Maria
Jose Teran, Francisco
JOURNAL OF PHYSICAL CHEMISTRY C, 2014, 118 (34): : 19985 - 19994
[33] Mushroom Carboxymethylated β-D-Glucan Functions as a Macrophage-Targeting Carrier for Iron Oxide Nanoparticles and an Inducer of Proinflammatory Macrophage Polarization for Immunotherapy
Su, Yuting
Yang, Fan
Chen, Lei
Cheung, Peter C. K.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2022, 70 (23) : 7110 - 7121
[34] Poly(γ-glutamic acid)-stabilized iron oxide nanoparticles: synthesis, characterization and applications for MR imaging of tumors
Yu, Zhibo
Peng, Chen
Luo, Yu
Zhu, Jianzhi
Chen, Chen
Shen, Mingwu
Shi, Xiangyang
RSC ADVANCES, 2015, 5 (94): : 76700 - 76707
[35] Pharmacokinetic modeling of phagocytic activity of the liver using superparamagnetic iron oxide nanoparticles in dynamic MR imaging
Na, JB
Suh, JS
Huh, YM
Kim, SJ
Kim, SH
Cha, SW
Lee, SH
YONSEI MEDICAL JOURNAL, 2003, 44 (03) : 429 - 437
[36] Ultra-high relaxivity iron oxide nanoparticles confined in polymer nanospheres for tumor MR imaging
Lin, Ying
Wang, Sanxi
Zhang, Yajun
Gao, Jiangang
Hong, Liu
Wang, Xin
Wu, Wei
Jiang, Xiqun
JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (28) : 5702 - 5710
[37] Modification of hyaluronic acid onto hydrothermally synthesized iron oxide nanoparticles for targeted tumor MR imaging
Li, Jingchao
He, Yao
Sun, Wenjie
Shen, Mingwu
Xia, Jindong
Shi, Xiangyang
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
[38] Fluorophore-tagged superparamagnetic iron oxide nanoparticles as bimodal contrast agents for MR/optical imaging
Parvin Eghbali
Hassan Fattahi
Sophie Laurent
Robert N. Muller
Yones Mosaei Oskoei
Journal of the Iranian Chemical Society, 2016, 13 : 87 - 93
[39] Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging
Li, Lei
Gao, Fumei
Jiang, Weiwei
Wu, Xueliang
Cai, Yuanyuan
Tang, Jintian
Gao, Xueyun
Gao, Fuping
DRUG DELIVERY, 2016, 23 (05) : 1726 - 1733
[40] Synthesis and characterization of dextran stabilized superparamagnetic iron oxide nanoparticles for in vivo MR imaging of liver fibrosis
Saraswathy, Ariya
Nazeer, Shaiju S.
Nimi, Nirmala
Arumugam, Sabareeswaran
Shenoy, Sachin J.
Jayasree, Ramapurath. S.
CARBOHYDRATE POLYMERS, 2014, 101 : 760 - 768

← 1 2 3 4 5 →