Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes

被引:2
|
作者
Nuszkiewicz, Jaroslaw [1 ]
Kukulska-Pawluczuk, Beata [2 ]
Piec, Katarzyna [2 ]
Jarek, Dorian Julian [3 ]
Motolko, Karina [4 ]
Szewczyk-Golec, Karolina [1 ]
Wozniak, Alina [1 ]
机构
[1] Nicolaus Copernicus Univ Torun, Fac Med, Dept Med Biol & Biochem, Ludwik Rydygier Coll Med Bydgoszcz, 24 Karlowicza St, PL-85092 Bydgoszcz, Poland
[2] Nicolaus Copernicus Univ Torun, Fac Med, Dept Neurol, Ludwik Rydygier Coll Med Bydgoszcz, 9 M Curie Sklodowskiej St, PL-85094 Bydgoszcz, Poland
[3] Nicolaus Copernicus Univ Torun, Fac Med, Dept Med Biol & Biochem, Ludwik Rydygier Coll Med Bydgoszcz, 24 Karlowicza St, PL-85092 Bydgoszcz, Poland
[4] Nicolaus Copernicus Univ Torun, Fac Med, Dept Neurol, Ludwik Rydygier Coll Med Bydgoszcz, 9 M Curie Sklodowskiej St, PL-85094 Bydgoszcz, Poland
关键词
acute ischemic stroke; adipokines; biomarkers; brain-gut axis; gastrointestinal microbiome; inflammation; lipopolysaccharides; metabolic dysregulation; neuroinflammation; obesity; SMALL VESSEL DISEASE; BLOOD-BRAIN-BARRIER; TOLL-LIKE RECEPTORS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; ATRIAL-FIBRILLATION; OXIDATIVE STRESS; RISK-FACTORS; INTRAVENOUS THROMBOLYSIS; CARDIOEMBOLIC STROKE;
D O I
10.3390/jcm13144258
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute ischemic stroke (AIS) remains a major cause of mortality and long-term disability worldwide, driven by complex and multifaceted etiological factors. Metabolic dysregulation, gastrointestinal microbiome alterations, and systemic inflammation are emerging as significant contributors to AIS pathogenesis. This review addresses the critical need to understand how these factors interact to influence AIS risk and outcomes. We aim to elucidate the roles of dysregulated adipokines in obesity, the impact of gut microbiota disruptions, and the neuroinflammatory cascade initiated by lipopolysaccharides (LPS) in AIS. Dysregulated adipokines in obesity exacerbate inflammatory responses, increasing AIS risk and severity. Disruptions in the gut microbiota and subsequent LPS-induced neuroinflammation further link systemic inflammation to AIS. Advances in neuroimaging and biomarker development have improved diagnostic precision. Here, we highlight the need for a multifaceted approach to AIS management, integrating metabolic, microbiota, and inflammatory insights. Potential therapeutic strategies targeting these pathways could significantly improve AIS prevention and treatment. Future research should focus on further elucidating these pathways and developing targeted interventions to mitigate the impacts of metabolic dysregulation, microbiome imbalances, and inflammation on AIS.
引用
收藏
页数:47
相关论文
共 50 条
  • [41] Applicability of the low-grade inflammation score in predicting 90-day functional outcomes after acute ischemic stroke
    Yang Zhou
    Yufan Luo
    Huazheng Liang
    Ping Zhong
    Danhong Wu
    BMC Neurology, 23
  • [42] Systemic Inflammation Response Index Predicts Clinical Outcomes in Patients With Acute Ischemic Stroke (AIS) After the Treatment of Intravenous Thrombolysis
    Chen, Yan-Fang
    Qi, Shuo
    Yu, Zi-Jian
    Li, Jiang-Tao
    Qian, Ting-Ting
    Zeng, Ying
    Cao, Peng
    NEUROLOGIST, 2023, 28 (06) : 355 - 361
  • [43] The joint effects of inflammation and renal function status on in-hospital outcomes in patients with acute ischemic stroke treated with intravenous thrombolysis
    Huang, Zhichao
    Zhu, Xiaoyue
    Xu, Xiuman
    Wang, Yi
    Zhu, Yafang
    Chen, Dongqin
    Cao, Yongjun
    Zhang, Xia
    BMC NEUROLOGY, 2024, 24 (01)
  • [44] Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes-Where is the data: A systematic review
    Dylla, Layne
    Higgins, Hannah M. M.
    Piper, Christi
    Poisson, Sharon N. N.
    Herson, Paco S. S.
    Monte, Andrew A. A.
    FRONTIERS IN NEUROLOGY, 2022, 13
  • [45] Association between Systemic Immune-Inflammation Index and Systemic Inflammation Response Index and Outcomes of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
    Han, Jian
    Yang, Liting
    Lou, Zhuocong
    Zhu, Yubo
    ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2023, 26 (05) : 655 - +
  • [46] The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke
    Peng, Xiapei
    Jing, Ping
    Chen, Juan
    Xu, Liwen
    JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2019, 33 (07)
  • [47] The Role of IL-6 and TNF-Alpha Biomarkers in Predicting Disability Outcomes in Acute Ischemic Stroke Patients
    Bacila, Ciprian-Ionut
    Vladoiu, Maria-Gabriela
    Valeanu, Madalina
    Moga, Doru-Florian-Cornel
    Pumnea, Pia-Manuela
    LIFE-BASEL, 2025, 15 (01):
  • [48] Predictive value of systemic immune-inflammation index for cerebral reperfusion and clinical outcomes in patients with acute ischemic stroke endovascular treatment
    Acar, B. A.
    Acar, T.
    Vatan, M. B.
    Aras, Y. G.
    Ula, S. B.
    Eryilmaz, H. A.
    Dalkilic, S.
    Zafer, A. P.
    Turhan, O.
    Vatan, A.
    Varim, P.
    Kaya, T.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2022, 26 (16) : 5718 - 5728
  • [49] Single-Cell RNA-Sequencing Analyses Revealed Heterogeneity and Dynamic Changes of Metabolic Pathways in Astrocytes at the Acute Phase of Ischemic Stroke
    Ma, Hongyu
    Zhou, Yu
    Li, Zifu
    Zhu, Luojiang
    Li, He
    Zhang, Guanghao
    Wang, Jing
    Gong, Haiyi
    Xu, Da
    Hua, Weilong
    Liu, Pei
    Zhang, Xiaoxi
    Zhang, Yongxin
    Zhang, Lei
    Hong, Bo
    Zhou, Wang
    Yang, Pengfei
    Liu, Jianmin
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
  • [50] Gastrointestinal Bowel Obstruction in Acute Ischemic Stroke: Incidence, Risk Factors, and Outcomes in a US Nationwide Analysis of 3,998,667 Hospitalizations
    Rumalla, Kavelin
    Kumar, Ashwath S.
    Mittal, Manoj K.
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2017, 26 (10): : 2093 - 2101