Intersecting Pathways: The Role of Metabolic Dysregulation, Gastrointestinal Microbiome, and Inflammation in Acute Ischemic Stroke Pathogenesis and Outcomes

被引:2
|
作者
Nuszkiewicz, Jaroslaw [1 ]
Kukulska-Pawluczuk, Beata [2 ]
Piec, Katarzyna [2 ]
Jarek, Dorian Julian [3 ]
Motolko, Karina [4 ]
Szewczyk-Golec, Karolina [1 ]
Wozniak, Alina [1 ]
机构
[1] Nicolaus Copernicus Univ Torun, Fac Med, Dept Med Biol & Biochem, Ludwik Rydygier Coll Med Bydgoszcz, 24 Karlowicza St, PL-85092 Bydgoszcz, Poland
[2] Nicolaus Copernicus Univ Torun, Fac Med, Dept Neurol, Ludwik Rydygier Coll Med Bydgoszcz, 9 M Curie Sklodowskiej St, PL-85094 Bydgoszcz, Poland
[3] Nicolaus Copernicus Univ Torun, Fac Med, Dept Med Biol & Biochem, Ludwik Rydygier Coll Med Bydgoszcz, 24 Karlowicza St, PL-85092 Bydgoszcz, Poland
[4] Nicolaus Copernicus Univ Torun, Fac Med, Dept Neurol, Ludwik Rydygier Coll Med Bydgoszcz, 9 M Curie Sklodowskiej St, PL-85094 Bydgoszcz, Poland
关键词
acute ischemic stroke; adipokines; biomarkers; brain-gut axis; gastrointestinal microbiome; inflammation; lipopolysaccharides; metabolic dysregulation; neuroinflammation; obesity; SMALL VESSEL DISEASE; BLOOD-BRAIN-BARRIER; TOLL-LIKE RECEPTORS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; ATRIAL-FIBRILLATION; OXIDATIVE STRESS; RISK-FACTORS; INTRAVENOUS THROMBOLYSIS; CARDIOEMBOLIC STROKE;
D O I
10.3390/jcm13144258
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute ischemic stroke (AIS) remains a major cause of mortality and long-term disability worldwide, driven by complex and multifaceted etiological factors. Metabolic dysregulation, gastrointestinal microbiome alterations, and systemic inflammation are emerging as significant contributors to AIS pathogenesis. This review addresses the critical need to understand how these factors interact to influence AIS risk and outcomes. We aim to elucidate the roles of dysregulated adipokines in obesity, the impact of gut microbiota disruptions, and the neuroinflammatory cascade initiated by lipopolysaccharides (LPS) in AIS. Dysregulated adipokines in obesity exacerbate inflammatory responses, increasing AIS risk and severity. Disruptions in the gut microbiota and subsequent LPS-induced neuroinflammation further link systemic inflammation to AIS. Advances in neuroimaging and biomarker development have improved diagnostic precision. Here, we highlight the need for a multifaceted approach to AIS management, integrating metabolic, microbiota, and inflammatory insights. Potential therapeutic strategies targeting these pathways could significantly improve AIS prevention and treatment. Future research should focus on further elucidating these pathways and developing targeted interventions to mitigate the impacts of metabolic dysregulation, microbiome imbalances, and inflammation on AIS.
引用
收藏
页数:47
相关论文
共 50 条
  • [1] The role of carotid plaque vulnerability and inflammation in the pathogenesis of acute ischemic stroke
    Ding, Shifang
    Zhang, Mei
    Zhao, Yuxia
    Chen, Wenqiang
    Yao, Guihua
    Zhang, Cheng
    Zhang, Pengfe
    Zhang, Yun
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2008, 336 (01): : 27 - 31
  • [2] The Role of Infection and Inflammation in the Pathogenesis of Pediatric Arterial Ischemic Stroke
    Cornet, Marie-Coralie
    Grose, Charles
    Vexler, Zinaida
    Wu, Yvonne W.
    Fullerton, Heather J.
    SEMINARS IN PEDIATRIC NEUROLOGY, 2022, 44
  • [3] The role of adhesion molecules in pathogenesis of acute ischemic stroke
    Basic-Kes, V.
    Simundic, A. M.
    Vargek-Solter, V.
    Topic, E.
    Demarin, V.
    EUROPEAN JOURNAL OF NEUROLOGY, 2004, 11 : 208 - 208
  • [4] Role of Nitric Oxide in the Pathogenesis of Acute Ischemic Stroke
    Maximov, G.
    NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS, 2008, 4 (01): : 44 - 47
  • [5] ROLE OF PROTEIN Z IN THE PATHOGENESIS OF ACUTE ISCHEMIC STROKE
    Zhang, C. B.
    Wen, F.
    Peng, H. F.
    Feng, J. R.
    He, J. T.
    JOURNAL OF NEUROCHEMISTRY, 2009, 110 : 175 - 175
  • [6] THE ROLE OF ORAL STREPTOCOCCI IN THE PATHOGENESIS OF ACUTE ISCHEMIC STROKE
    Patrakka, O.
    Tuomisto, S.
    Pienimaki, J. -P.
    Ollikainen, J.
    Oksala, N.
    Lehtimaki, T.
    Martiskainen, M.
    Karhunen, P.
    INTERNATIONAL JOURNAL OF STROKE, 2022, 17 (3_SUPPL) : 39 - 39
  • [7] Role of Inflammation and Its Mediators in Acute Ischemic Stroke
    Jin, Rong
    Liu, Lin
    Zhang, Shihao
    Nanda, Anil
    Li, Guohong
    JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2013, 6 (05) : 834 - 851
  • [8] Role of Inflammation and Its Mediators in Acute Ischemic Stroke
    Rong Jin
    Lin Liu
    Shihao Zhang
    Anil Nanda
    Guohong Li
    Journal of Cardiovascular Translational Research, 2013, 6 : 834 - 851
  • [9] Deleterious Effect of Smoking on Ischemic Stroke Outcomes: Implications for the Role of Chronic Inflammation on Atherosclerotic Plaque Pathogenesis
    Ding, Dale
    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2014, 23 (03): : 596 - 597
  • [10] Role of Pial Collateral Flow in Acute Ischemic Stroke Outcomes
    Modi, Sumul
    Marin, Horia
    Varelas, Panayiotis
    Mitsias, Panayiotis
    STROKE, 2017, 48