Photocatalytic Three-Component Acylcarboxylation of Alkenes with CO2

被引：3
|
作者：
Watanabe, Taito [1 ]
Lorwongkamol, Phurinat [1 ]
Saga, Yutaka [1 ,4 ]
Kosugi, Kento [1 ,2 ]
Kambe, Tetsuya [1 ,3 ]
Kondo, Mio [1 ,2 ,4 ]
Masaoka, Shigeyuki [1 ,4 ]
机构：
[1] Osaka Univ, Grad Sch Engn, Div Appl Chem, Suita, Osaka 5650871, Japan
[2] Tokyo Inst Technol, Sch Sci, Dept Chem, Meguro Ku, Tokyo 1528551, Japan
[3] Osaka Univ, Fac Engn, Ctr Future Innovat CFi, Dept Appl Chem, Suita, Osaka 5650871, Japan
[4] Osaka Univ, Inst Open & Transdisciplinary Res Initiat ICS OTRI, Innovat Catalysis Sci Div, Suita, Osaka 5650871, Japan
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 30期
基金：
日本科学技术振兴机构; 日本学术振兴会;
关键词：
PHOTOREDOX-CATALYZED DICARBOFUNCTIONALIZATION; GAMMA-KETO ACIDS; AMINO-ACIDS; STYRENES; ECONOMY; ESTERS; ATOM;
D O I：
10.1021/acs.orglett.4c02295
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
gamma-Keto acid is a valuable chemical motif in a wide range of fields including organic, biological, and medicinal chemistry. However, its single-step synthesis is challenging because of the mismatch of the carbonyl polarity and low tolerance of carboxylic acids. Herein, we report the single-step syntheses of gamma-keto acids using alkenes and CO2. Our photocatalytic system enabled the transformation of alkenes under mild conditions in high yields (up to 95%) with broad substrate generality (35 examples).
引用
收藏
页码：6491 / 6496
页数：6
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