Development of in vitro biopharmaceutics tools for predicting the bioavailability of subcutaneously injected monoclonal antibodies and oligonucleotides

被引：0

作者：

Somby, Karin ^{[1
,2
]}

Campagna, Valerio ^{[2
]}

Sanchez-Felix, Manuel V. ^{[3
,4
]}

Forbes, Ben ^{[1
]}

Vllasaliu, Driton ^{[1
]}

机构：

[1] Kings Coll London, Inst Pharmaceut Sci, Franklin Wilkins Bldg,150 Stamford St, London SE1 9NH, England

[2] Novartis Pharm AG, Basel, Switzerland

[3] Novartis Pharm AG, Cambridge, MA USA

[4] Halozyme Therapeut, San Diego, CA USA

来源：

关键词：

SiRNA; GalNAc; mAbs; Biologics; Absorption; Pharmacokinetics; Physiologically based biopharmaceutics modeling (PBBM); SCISSOR; MODEL;

D O I：

10.1080/17425247.2024.2403469

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：1307 / 1310

页数：4