Mechanisms of Stem Cells and Their Secreted Exosomes in the Treatment of Autoimmune Diseases

被引：0
|
作者：
Lin, Shu-Qian [1 ]
Wang, Kai [1 ]
Pan, Xing-Hua [2 ,3 ]
Ruan, Guang-Ping [2 ,3 ]
机构：
[1] Kunming Med Univ, Clin Coll Hosp 920, Kunming 650032, Yunnan, Peoples R China
[2] PLA, Basic Med Lab, Hosp Joint Logist Support Force 920, Kunming 650032, Yunnan, Peoples R China
[3] Stem Cells & Immune Cells Biomed Tech Integrated E, Kunming, Peoples R China
来源：
CURRENT STEM CELL RESEARCH & THERAPY | 2024年 / 19卷 / 11期
关键词：
Hematopoietic stem cells; mesenchymal stem cells; diabetes; systemic lupus erythematosus; inflammatory bowel disease; therapy; exosome; REFRACTORY RHEUMATOID-ARTHRITIS; PROGENITOR CELLS; BONE-MARROW; HEMATOPOIETIC STEM; LUPUS; INDUCTION; THERAPY; COLITIS; SAFETY;
D O I：
10.2174/011574888X271344231129053003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Stem cells play a therapeutic role in many diseases by virtue of their strong self-renewal and differentiation abilities, especially in the treatment of autoimmune diseases. At present, the mechanism of the stem cell treatment of autoimmune diseases mainly relies on their immune regulation ability, regulating the number and function of auxiliary cells, anti-inflammatory factors and proinflammatory factors in patients to reduce inflammation. On the other hand, the stem cell-derived secretory body has weak immunogenicity and low molecular weight, can target the site of injury, and can extend the length of its active time in the patient after combining it with the composite material. Therefore, the role of secretory bodies in the stem cell treatment of autoimmune diseases is increasingly important.
引用
收藏
页码：1415 / 1428
页数：14
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