Is there a role for mesenchymal stem cells in autoimmune diseases?

被引：32
|
作者：
Uccelli, Antonio [1 ,2 ]
Mancardi, Gianluigi [1 ]
Chiesa, Sabrina [1 ,2 ]
机构：
[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16132 Genoa, Italy
[2] Adv Biotechnol Ctr, I-16132 Genoa, Italy
来源：
AUTOIMMUNITY | 2008年 / 41卷 / 08期
关键词：
Mesenchymal stem cell; bone marrow; autoimmune diseases; multiple sclerosis; experimental autoimmune encephalomyelitis;
D O I：
10.1080/08916930802200166
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent reports have highlighted that adult stem cells are granted with yet poorly understood properties other than multipotentiality. In particular, mesenchymal stem cells (MSCs) represent a subset of adult stromal cells that can down-regulate several functions of the immune cells. In addition, MSCs may promote survival of damaged cells and tissues through paracrine mechanisms, possibly under the guidance of environmental cues. Thus, MSCs clinical application in autoimmune diseases seems an appealing opportunity and preclinical results in different experimental models of autoimmunity further support this strategy. Despite the absolute need for caution related to several clinical and technical issues, MSCs are now on the edge of a new era of clinical applications.
引用
收藏
页码：592 / 595
页数：4
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