Coaching LSD1 to ignore acetylation

被引:0
|
作者
Black, Joshua C. [1 ]
Kutateladze, Tatiana G. [1 ]
机构
[1] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA
关键词
D O I
10.1038/s41589-024-01710-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Engineered demethylase LSD1 opens a new avenue in developing tools to study intricate relationships between histone post-translational modifications that can be enzymatically edited.
引用
收藏
页码:162 / 163
页数:2
相关论文
共 50 条
  • [41] Targeting LSD1 and FOXA1 in prostate cancer
    Omarjee, Soleilmane
    Carroll, Jason S.
    NATURE GENETICS, 2020, 52 (10) : 1002 - 1003
  • [42] Silencing of LSD1 gene modulates histone methylation and acetylation and induces the apoptosis of JeKo-1 and MOLT-4 cells
    Zou, Zhong-Kai
    Huang, Yi-Qun
    Zou, Yong
    Zheng, Xu-Ke
    Ma, Xu-Dong
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 40 (02) : 319 - 328
  • [43] Targeting LSD1 and FOXA1 in prostate cancer
    Soleilmane Omarjee
    Jason S. Carroll
    Nature Genetics, 2020, 52 : 1002 - 1003
  • [44] LSD1 protects against hippocampal and cortical neurodegeneration
    Michael A. Christopher
    Dexter A. Myrick
    Benjamin G. Barwick
    Amanda K. Engstrom
    Kirsten A. Porter-Stransky
    Jeremy M. Boss
    David Weinshenker
    Allan I. Levey
    David J. Katz
    Nature Communications, 8
  • [45] Natural products as LSD1 inhibitors for cancer therapy
    Fang, Yuan
    Yang, Chao
    Yu, Zhiqiang
    Li, Xiaochuan
    Mu, Qingchun
    Liao, Guochao
    Yu, Bin
    ACTA PHARMACEUTICA SINICA B, 2021, 11 (03) : 621 - 631
  • [46] LSD1 is required for chromosome segregation during mitosis
    Lv, Shuang
    Bu, Wenjuan
    Jiao, Hong
    Liu, Bo
    Zhu, Lin
    Zhao, Hongchang
    Liao, Ji
    Li, Jing
    Xu, Xingzhi
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2010, 89 (07) : 557 - 563
  • [47] THE ROLE OF LSD1 IN MAINTAINING ERYTHROID FATE COMMITMENT
    Thompson, Evrett
    Krause, Diane
    EXPERIMENTAL HEMATOLOGY, 2022, 111 : S147 - S147
  • [48] Natural products as LSD1 inhibitors for cancer therapy
    Yuan Fang
    Chao Yang
    Zhiqiang Yu
    Xiaochuan Li
    Qingchun Mu
    Guochao Liao
    Bin Yu
    Acta Pharmaceutica Sinica B, 2021, 11 (03) : 621 - 631
  • [49] LSD1 inhibition in pHGG: the key to unleashing immunotherapy?
    Nicolaides, Theodore P.
    Hashizume, Rintaro
    NEURO-ONCOLOGY, 2020, 22 (09) : 1237 - 1238
  • [50] Targeting oral cancer epigenome via LSD1
    Bais, Manish V.
    AGING-US, 2017, 9 (12): : 2455 - 2456