Targeting LSD1 and FOXA1 in prostate cancer

被引：3
|
作者：
Omarjee, Soleilmane [1 ]
Carroll, Jason S. [1 ]
机构：
[1] Univ Cambridge, Canc Res UK Cambridge Inst, Cambridge, England
来源：
NATURE GENETICS | 2020年 / 52卷 / 10期
关键词：
D O I：
10.1038/s41588-020-0702-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
FOXA1 is a key pioneer factor in androgen-receptor activity but has been an elusive drug target. A new study shows that inhibition of the associated cofactor LSD1 modifies the methylation state of FOXA1, thus resulting in chromatin dissociation and tumor inhibition, even in models of treatment-resistant prostate cancer.
引用
收藏
页码：1002 / 1003
页数：2
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