Evaluating the efficacy of immunotherapy in gastric cancer: Insights from immune checkpoint inhibitors

被引:0
|
作者
Yang, Yu-Nuo [1 ]
Wang, Li-Sheng [2 ]
Dang, Yan-Qi [1 ]
Ji, Guang [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, China Canada Ctr Res Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China
[2] Univ Ottawa, Dept Biochem, Ottawa, ON K1H 8M5, Canada
关键词
Gastric cancer; Immune checkpoint inhibitors; Sarcopenia; Myosteatosis; Prediction model;
D O I
10.3748/wjg.v30.i32.3726
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The emergence of immunotherapy, particularly immune checkpoint inhibitors (ICIs), represents a groundbreaking approach to treating gastric cancer (GC). However, the prognosis of GC patients receiving ICI treatment is influenced by various factors. This manuscript identified sarcopenia and myosteatosis as inde-pendent prognostic factors impacting the outcomes of GC patients treated with ICIs. Additionally, this study introduced a visual predictive model to estimate the prognosis of GC patients. If confirmed by further studies, this observation could provide valuable insights to propel the advancement of personalized clinical medicine and the integration of precision medicine practices.
引用
收藏
页数:5
相关论文
共 50 条
  • [21] Growth hormone associated with treatment efficacy of immune checkpoint inhibitors in gastric cancer patients
    Zhao, Yue
    Ji, Zhengzheng
    Li, Jiasong
    Zhang, Shasha
    Wu, Chensi
    Zhang, Ruixing
    Guo, Zhanjun
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [22] The rest period between chemotherapy and immunotherapy influences the efficacy of immune checkpoint inhibitors in lung cancer
    Kang, Da Hyun
    Choi, Seong-woo
    Sun, Pureum
    Chung, Chaeuk
    Park, Dongil
    Lee, Song-, I
    Koh, Jeong Suk
    Kim, Yoonjoo
    Lee, Jeong Eun
    THORACIC CANCER, 2022, 13 (16) : 2346 - 2354
  • [23] Efficacy and adverse events of immune checkpoint inhibitors in esophageal cancer patients: Challenges and perspectives for immunotherapy
    Ma, Yingjie
    Yu, Junxian
    Ma, Xiaoting
    Li, Qin
    Su, Qiang
    Cao, Bangwei
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2024, 20 (02) : 180 - 187
  • [24] Current status of immune checkpoint inhibitors for gastric cancer
    Koji Kono
    Shotaro Nakajima
    Kosaku Mimura
    Gastric Cancer, 2020, 23 : 565 - 578
  • [25] Current status of immune checkpoint inhibitors for gastric cancer
    Kono, Koji
    Nakajima, Shotaro
    Mimura, Kosaku
    GASTRIC CANCER, 2020, 23 (04) : 565 - 578
  • [26] Efficacy of immunotherapy (IT) after prior immune checkpoint inhibitors (ICIs) exposure
    Hernando-Calvo, A.
    Valdivia, A.
    Santa Gadea, O. Saavedra
    Brana, I.
    Berche, R.
    Matos, I.
    Vieito, M.
    Azaro Pedrazzoli, A. B.
    Alonso Casal, G.
    Galvao, V.
    Diez Garcia, M.
    Verdaguer, H.
    Ortiz Velez, C.
    Gonzalez, M.
    Baraibar Argota, I.
    Callejo, A.
    Munoz Couselo, E.
    Tabernero, J.
    Dienstmann, R.
    Garralda, E.
    ANNALS OF ONCOLOGY, 2020, 31 : S489 - S490
  • [27] Combination of photosensitizer and immune checkpoint inhibitors for improving the efficacy of tumor immunotherapy
    Li, Kexin
    Yu, Huan
    Bao, Zhihong
    Xu, Lu
    Zhang, Hong
    Wang, Tian
    Yu, Longyue
    Yuan, Yue
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 629
  • [28] Efficacy and toxicity of immunotherapy with immune checkpoint inhibitors in gynecologic cancers.
    Kuznicki, Michelle
    Joehlin-Price, Amy
    Rose, Peter Graham
    Mahdi, Haider
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [29] Rheumatic adverse events of immune checkpoint inhibitors in cancer immunotherapy
    Abdel-Wahab, Noha
    Suarez-Almazor, Maria E.
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2024, 20 (08) : 873 - 893
  • [30] Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
    Elena Catanzaro
    Manuel Beltrán-Visiedo
    Lorenzo Galluzzi
    Dmitri V. Krysko
    Cellular & Molecular Immunology, 2025, 22 (1) : 24 - 39