Evaluating the efficacy of immunotherapy in gastric cancer: Insights from immune checkpoint inhibitors

被引:0
|
作者
Yang, Yu-Nuo [1 ]
Wang, Li-Sheng [2 ]
Dang, Yan-Qi [1 ]
Ji, Guang [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, China Canada Ctr Res Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China
[2] Univ Ottawa, Dept Biochem, Ottawa, ON K1H 8M5, Canada
关键词
Gastric cancer; Immune checkpoint inhibitors; Sarcopenia; Myosteatosis; Prediction model;
D O I
10.3748/wjg.v30.i32.3726
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The emergence of immunotherapy, particularly immune checkpoint inhibitors (ICIs), represents a groundbreaking approach to treating gastric cancer (GC). However, the prognosis of GC patients receiving ICI treatment is influenced by various factors. This manuscript identified sarcopenia and myosteatosis as inde-pendent prognostic factors impacting the outcomes of GC patients treated with ICIs. Additionally, this study introduced a visual predictive model to estimate the prognosis of GC patients. If confirmed by further studies, this observation could provide valuable insights to propel the advancement of personalized clinical medicine and the integration of precision medicine practices.
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Application of immune checkpoint inhibitors in immunotherapy for gastric cancer
    Wu, Yi-Xiang
    Zhou, Xiao-Yu
    Wang, Jian-Qi
    Chen, Gao-Min
    Chen, Jin-Xu
    Wang, Rong-Chang
    Huang, Jiong-Qiang
    Chen, Jing-Song
    IMMUNOTHERAPY, 2023, 15 (02) : 101 - 115
  • [2] Immune checkpoint inhibitors in cancer immunotherapy
    Himmel, Megan E.
    Saibil, Samuel D.
    Saltman, Alexandra P.
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 2020, 192 (24) : E651 - E651
  • [3] Immunotherapy Based on Immune Checkpoint Molecules and Immune Checkpoint Inhibitors in Gastric Cancer-Narrative Review
    Poniewierska-Baran, Agata
    Sobolak, Karolina
    Niedzwiedzka-Rystwej, Paulina
    Plewa, Paulina
    Pawlik, Andrzej
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (12)
  • [4] Statins and immune checkpoint inhibitors: a strategy to improve the efficacy of immunotherapy for cancer?
    Vos, Winnie G.
    Lutgens, Esther
    Seijkens, Tom T. P.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (09)
  • [5] Cancer immunotherapy beyond immune checkpoint inhibitors
    Marin-Acevedo, Julian A.
    Soyano, Aixa E.
    Dholaria, Bhagirathbhai
    Knutson, Keith L.
    Lou, Yanyan
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2018, 11
  • [6] Cancer immunotherapy beyond immune checkpoint inhibitors
    Julian A. Marin-Acevedo
    Aixa E. Soyano
    Bhagirathbhai Dholaria
    Keith L. Knutson
    Yanyan Lou
    Journal of Hematology & Oncology, 11
  • [7] Immune checkpoint inhibitors and cellular immunotherapy for advanced gastric, gastroesophageal cancer: a long pathway
    Runzi Cheng
    Baizhi Li
    Huaiming Wang
    Yongming Zeng
    Clinical and Translational Oncology, 2023, 25 : 3122 - 3138
  • [8] Immune checkpoint inhibitors and cellular immunotherapy for advanced gastric, gastroesophageal cancer: a long pathway
    Cheng, Runzi
    Li, Baizhi
    Wang, Huaiming
    Zeng, Yongming
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2023, 25 (11): : 3122 - 3138
  • [9] Rheumatic Manifestations and Diseases From Immune Checkpoint Inhibitors in Cancer Immunotherapy
    Shen, Pan
    Deng, Xuan
    Hu, Zhishuo
    Chen, Zhe
    Huang, Yao
    Wang, Ke
    Qin, Kai
    Huang, Ying
    Ba, Xin
    Yan, Jiahui
    Han, Liang
    Tu, Shenghao
    FRONTIERS IN MEDICINE, 2021, 8
  • [10] Resistance to immune checkpoint inhibitors in gastric cancer
    Liu, Kai
    Yuan, Shiman
    Wang, Chenyu
    Zhu, Hong
    FRONTIERS IN PHARMACOLOGY, 2023, 14