The N-(Benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)amino)butanamide

被引：0

作者：

Pilotzi-Xahuentitla, Hugo ^{[1
]}

Canche-Naal, Gabriela del Carmen ^{[2
]}

Ortiz-Andrade, Rolffy Ruben ^{[2
]}

Navarrete-Vazquez, Gabriel ^{[3
]}

Hernandez-Nunez, Emanuel ^{[4
]}

机构：

[1] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Recursos Mar, Merida 97310, Yucatan, Mexico

[2] Univ Autonoma Yucatan, Fac Quim, Lab Farmacol, Merida 97069, Yucatan, Mexico

[3] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca 62209, Morelos, Mexico

[4] Inst Tecnol Super Calkini, Dept Posgrad Invest, Av Ah Canul S-N Carretera Fed, Campeche 24930, Mexico

来源：

MOLBANK | 2024年 / 2024卷 / 03期

关键词：

benzothiazole; benzoxazole; antidiabetic; molecular docking; EFFICIENT;

D O I：

10.3390/M1854

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained at a 76% global yield using accessible starting materials and a methodology in two reaction steps. Furthermore, we conducted docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent.

引用

页数：6

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