ORGANIC PHOSPHORUS-COMPOUNDS .4. ASYMMETRIC 4-(BENZOTHIAZOL-2-YL)BENZYLPHOSPHONATES AS POTENT CALCIUM ANTAGONISTIC VASODILATORS

被引：2
|
作者：
YOSHINO, K
GOTO, K
KOHNO, T
MORITA, T
TSUKAMOTO, G
机构：
[1] Pharmaceuticals Research Center, Kanebo Ltd., Miyakojima-ku, Osaka 534, 1-5-90, Tomobuchi-cho
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 03期
关键词：
benzothiazole; calcium antagonist; coronary vasodilator; fostedil; phosphonate; phosphonic acid;
D O I：
10.1248/cpb.38.676
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil. © 1990, The Pharmaceutical Society of Japan. All rights reserved.
引用
收藏
页码：676 / 680
页数：5
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