Decarboxylation in Natural Products Biosynthesis

被引：0
|
作者：
Nguyen, Nguyet A. [1 ]
Forstater, Jacob H. [2 ]
McIntosh, John A. [1 ]
机构：
[1] Merck & Co Inc, Boston, MA 02115 USA
[2] Merck & Co Inc, Rahway, NJ 07065 USA
来源：
JACS AU | 2024年 / 4卷 / 08期
关键词：
decarboxylation; natural product; biosynthesis; thiamine pyrophosphate; pyridoxal 5 '-phosphate; prenylated FMN; homolytic decarboxylation; oxidative decarboxylation; photodecarboxylase; cofactor-independent decarboxylase; S-ADENOSYLMETHIONINE PROTEIN; MEDIUM-CHAIN; 1-ALKENES; P BOND FORMATION; GENE-CLUSTER; PHOSPHONOPYRUVATE DECARBOXYLASE; PEPTIDE SYNTHETASE; XYLOSE SYNTHASE; PHAGE DISPLAY; FATTY-ACIDS; MICROCIN C;
D O I：
10.1021/jacsau.4c00425
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Decarboxylation reactions are frequently found in the biosynthesis of primary and secondary metabolites. Decarboxylase enzymes responsible for these transformations operate via diverse mechanisms and act on a large variety of substrates, making them appealing in terms of biotechnological applications. This Perspective focuses on the occurrence of decarboxylation reactions in natural product biosynthesis and provides a perspective on their applications in biocatalysis for fine chemicals and pharmaceuticals.
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页码：2715 / 2745
页数：31
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