Decarboxylation in Natural Products Biosynthesis

被引：0

作者：

Nguyen, Nguyet A. ^{[1
]}

Forstater, Jacob H. ^{[2
]}

McIntosh, John A. ^{[1
]}

机构：

[1] Merck & Co Inc, Boston, MA 02115 USA

[2] Merck & Co Inc, Rahway, NJ 07065 USA

来源：

JACS AU | 2024年 / 4卷 / 08期

关键词：

decarboxylation; natural product; biosynthesis; thiamine pyrophosphate; pyridoxal 5 '-phosphate; prenylated FMN; homolytic decarboxylation; oxidative decarboxylation; photodecarboxylase; cofactor-independent decarboxylase; S-ADENOSYLMETHIONINE PROTEIN; MEDIUM-CHAIN; 1-ALKENES; P BOND FORMATION; GENE-CLUSTER; PHOSPHONOPYRUVATE DECARBOXYLASE; PEPTIDE SYNTHETASE; XYLOSE SYNTHASE; PHAGE DISPLAY; FATTY-ACIDS; MICROCIN C;

D O I：

10.1021/jacsau.4c00425

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Decarboxylation reactions are frequently found in the biosynthesis of primary and secondary metabolites. Decarboxylase enzymes responsible for these transformations operate via diverse mechanisms and act on a large variety of substrates, making them appealing in terms of biotechnological applications. This Perspective focuses on the occurrence of decarboxylation reactions in natural product biosynthesis and provides a perspective on their applications in biocatalysis for fine chemicals and pharmaceuticals.

引用

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页码：2715 / 2745

页数：31

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