Intratympanic Lidocaine as a Potent Remedy for Tinnitus in Sudden Sensorineural Hearing Loss: A Double-Blind, Randomized Clinical Trial

被引:2
|
作者
Zhang, Di [1 ]
Li, Daibo [1 ]
Chen, Ting [1 ]
Feng, Xuefei [1 ]
Zhang, Juan [1 ]
机构
[1] Meishan Municipal Peoples Hosp, Dept Otorhinolaryngol Head & Neck Surg, Dongpo Rd, Meishan 620000, Sichuan, Peoples R China
关键词
Lidocaine; Sudden sensorineural hearing loss; Tinnitus; INTRAVENOUS LIDOCAINE; DIAGNOSIS;
D O I
10.1097/MAO.0000000000004283
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
ObjectiveThis study evaluates intratympanic lidocaine's efficacy and safety for tinnitus relief in sudden sensorineural hearing loss (SSNHL) patients.MethodsIn a double-blind randomized controlled trial, 100 SSNHL patients with unilateral tinnitus received either intratympanic lidocaine or saline plus usual care. Treatment impact was assessed at 1 and 3 months using the Tinnitus Handicap Inventory, subjective visual analog scale, pure-tone audiometry.ResultsThe lidocaine group demonstrated significant tinnitus relief according to the Tinnitus Handicap Inventory and visual analog scale, without pure-tone audiometry improvement or serious adverse events throughout the study period.ConclusionIntratympanic lidocaine provides a safe, efficacious treatment option for SSNHL tinnitus. Further studies should refine the dosage and delivery parameters because of SSNHL's heterogenous nature.
引用
收藏
页码:849 / 854
页数:6
相关论文
共 50 条
  • [11] Oral vs Intratympanic Corticosteroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss A Randomized Trial
    Rauch, Steven D.
    Halpin, Christopher F.
    Antonelli, Patrick J.
    Babu, Seilesh
    Carey, John P.
    Gantz, Bruce J.
    Goebel, Joel A.
    Hammerschlag, Paul E.
    Harris, Jeffrey P.
    Isaacson, Brandon
    Lee, Daniel
    Linstrom, Christopher J.
    Parnes, Lorne S.
    Shi, Helen
    Slattery, William H.
    Telian, Steven A.
    Vrabec, Jeffrey T.
    Reda, Domenic J.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (20): : 2071 - 2079
  • [12] Intratympanic dexamethasone for sudden sensorineural hearing loss: Clinical and laboratory evaluation
    Chandrasekhar, SS
    OTOLOGY & NEUROTOLOGY, 2001, 22 (01) : 18 - 23
  • [13] Intratympanic methylprednisolone acetate versus intratympanic lidocaine in the treatment of idiopathic subjective unilateral tinnitus of less than 1-year duration: a randomized, double-blind, clinical trial
    El Hennawi D.E.D.M.
    Ahmed M.R.
    Abdelkafy W.
    Geneid A.
    Ibrahim I.H.
    The Egyptian Journal of Otolaryngology, 2017, 33 (3) : 564 - 568
  • [14] Dexamethasone eardrop with grommet placement vs intratympanic steroid injection for sudden sensorineural hearing loss: A randomized prospective clinical trial
    Chang, Wai Tsz
    Zee, Benny
    Lee, Herbert S. H.
    Tong, Michael C. F.
    AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2020, 41 (04)
  • [15] Intratympanic Triamcinolone or Dexamethasone in Sudden Sensory Neural Hearing Loss: A Randomized Clinical Trial
    Emami, Hamed
    Tajdini, Ardavan
    Amirzargar, Behrooz
    Habibi, Saleh
    Varpaei, Hesam Aldin
    Gholami, Reza
    Karimi, Ahang
    Zadeh, Saber Jazini
    Mehrban, Amir Hosein
    INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, 2023, 75 (04) : 3545 - 3552
  • [16] Lidocaine for systemic sclerosis: a double-blind randomized clinical trial
    Riera, Rachel
    Andrade, Luis E. C.
    Souza, Alexandre W. S.
    Kayser, Cristiane
    Yanagita, Edison T.
    Trevisani, Virginia F. M.
    ORPHANET JOURNAL OF RARE DISEASES, 2011, 6
  • [17] Intratympanic Triamcinolone or Dexamethasone in Sudden Sensory Neural Hearing Loss: A Randomized Clinical Trial
    Hamed Emami
    Ardavan Tajdini
    Behrooz Amirzargar
    Saleh Habibi
    Hesam Aldin Varpaei
    Reza Gholami
    Ahang Karimi
    Saber Jazini Zadeh
    Amir Hosein Mehrban
    Indian Journal of Otolaryngology and Head & Neck Surgery, 2023, 75 : 3545 - 3552
  • [18] Lidocaine for systemic sclerosis: a double-blind randomized clinical trial
    Rachel Riera
    Luís EC Andrade
    Alexandre WS Souza
    Cristiane Kayser
    Edison T Yanagita
    Virgínia FM Trevisani
    Orphanet Journal of Rare Diseases, 6
  • [19] The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial
    Petridou, Anna I.
    Zagora, Eleftheria T.
    Petridis, Petros
    Korres, George S.
    Gazouli, Maria
    Xenelis, Ioannis
    Kyrodimos, Efthymios
    Kontothanasi, Georgia
    Kaliora, Andriana C.
    NUTRIENTS, 2019, 11 (12)
  • [20] Tinnitus Suppression Effect of Hearing Aids in Patients With High-frequency Hearing Loss: A Randomized Double-blind Controlled Trial
    Yakunina, Natalia
    Lee, Woo Hyun
    Ryu, Yoon-Jong
    Nam, Eui-Cheol
    OTOLOGY & NEUROTOLOGY, 2019, 40 (07) : 865 - 871