Synthesis of Hexafluoroisopropyl Aryl Ethers via Dual Photoredox/Nickel-Catalyzed C-O Coupling

被引：1

作者：

He, Xu ^{[1
]}

Zhang, Yu-Yang ^{[1
]}

Shou, Jia-Yi ^{[1
]}

Chu, Lingling ^{[2
]}

Qing, Feng-Ling ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Fluorine & Nitrogen Chem & Adv Mat, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem & Chem Engn, Ctr Adv Low Dimens Mat, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 31期

基金：

中国国家自然科学基金;

关键词：

RILUZOLE; ALCOHOLS;

D O I：

10.1021/acs.orglett.4c02553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report a photoredox/nickel-catalyzed cross-coupling of aryl bromides with 1,1,1,3,3,3-hexafluoroisopropanol for the construction of hexafluoroisopropyl aryl ethers. The mild reaction conditions employed allow for the applicability of a wide range of aryl and heteroaryl bromides. Late-stage functionalization and preliminary mechanistic studies have been demonstrated.

引用

页码：6782 / 6786

页数：5

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