Synthesis of Hexafluoroisopropyl Aryl Ethers via Dual Photoredox/Nickel-Catalyzed C-O Coupling

被引：1
|
作者：
He, Xu [1 ]
Zhang, Yu-Yang [1 ]
Shou, Jia-Yi [1 ]
Chu, Lingling [2 ]
Qing, Feng-Ling [1 ]
机构：
[1] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Fluorine & Nitrogen Chem & Adv Mat, Shanghai 200032, Peoples R China
[2] Donghua Univ, Coll Chem & Chem Engn, Ctr Adv Low Dimens Mat, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 31期
基金：
中国国家自然科学基金;
关键词：
RILUZOLE; ALCOHOLS;
D O I：
10.1021/acs.orglett.4c02553
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we report a photoredox/nickel-catalyzed cross-coupling of aryl bromides with 1,1,1,3,3,3-hexafluoroisopropanol for the construction of hexafluoroisopropyl aryl ethers. The mild reaction conditions employed allow for the applicability of a wide range of aryl and heteroaryl bromides. Late-stage functionalization and preliminary mechanistic studies have been demonstrated.
引用
收藏
页码：6782 / 6786
页数：5
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