Pancreatic Cancer: A Review of Risk Factors

被引:3
|
作者
Grigorescu, Raluca Roxana [1 ]
Husar-Sburlan, Ioana Alexandra [2 ]
Gheorghe, Cristian [3 ]
机构
[1] Carol Davila Univ Med & Pharm, Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 020021, Romania
[2] Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 011172, Romania
[3] Carol Davila Univ Med & Pharm, Fundeni Clin Inst, Ctr Digest Dis & Liver Transplantat, Bucharest 020021, Romania
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
pancreatic cancer; risk factors; obesity; microbiota; diabetes; PAPILLARY MUCINOUS NEOPLASMS; RENIN-ANGIOTENSIN SYSTEM; ABO BLOOD-GROUP; IMPAIRED GLUCOSE-TOLERANCE; BRCA2 GERMLINE MUTATIONS; PEUTZ-JEGHERS-SYNDROME; LONG-TERM SURVIVAL; HEPATITIS-B-VIRUS; FACTOR-I RECEPTOR; VITAMIN-D STATUS;
D O I
10.3390/life14080980
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pancreatic adenocarcinoma is one of the most lethal types of gastrointestinal cancer despite the latest medical advances. Its incidence has continuously increased in recent years in developed countries. The location of the pancreas can result in the initial symptoms of neoplasia being overlooked, which can lead to a delayed diagnosis and a subsequent reduction in the spectrum of available therapeutic options. The role of modifiable risk factors in pancreatic cancer has been extensively studied in recent years, with smoking and alcohol consumption identified as key contributors. However, the few screening programs that have been developed focus exclusively on genetic factors, without considering the potential impact of modifiable factors on disease occurrence. Thus, fully understanding and detecting the risk factors for pancreatic cancer represents an important step in the prevention and early diagnosis of this type of neoplasia. This review reports the available evidence on different risk factors and identifies the areas that could benefit the most from additional studies.
引用
收藏
页数:34
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