Pancreatic Cancer: A Review of Risk Factors

被引:3
|
作者
Grigorescu, Raluca Roxana [1 ]
Husar-Sburlan, Ioana Alexandra [2 ]
Gheorghe, Cristian [3 ]
机构
[1] Carol Davila Univ Med & Pharm, Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 020021, Romania
[2] Sfanta Maria Hosp, Gastroenterol Dept, Bucharest 011172, Romania
[3] Carol Davila Univ Med & Pharm, Fundeni Clin Inst, Ctr Digest Dis & Liver Transplantat, Bucharest 020021, Romania
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
pancreatic cancer; risk factors; obesity; microbiota; diabetes; PAPILLARY MUCINOUS NEOPLASMS; RENIN-ANGIOTENSIN SYSTEM; ABO BLOOD-GROUP; IMPAIRED GLUCOSE-TOLERANCE; BRCA2 GERMLINE MUTATIONS; PEUTZ-JEGHERS-SYNDROME; LONG-TERM SURVIVAL; HEPATITIS-B-VIRUS; FACTOR-I RECEPTOR; VITAMIN-D STATUS;
D O I
10.3390/life14080980
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pancreatic adenocarcinoma is one of the most lethal types of gastrointestinal cancer despite the latest medical advances. Its incidence has continuously increased in recent years in developed countries. The location of the pancreas can result in the initial symptoms of neoplasia being overlooked, which can lead to a delayed diagnosis and a subsequent reduction in the spectrum of available therapeutic options. The role of modifiable risk factors in pancreatic cancer has been extensively studied in recent years, with smoking and alcohol consumption identified as key contributors. However, the few screening programs that have been developed focus exclusively on genetic factors, without considering the potential impact of modifiable factors on disease occurrence. Thus, fully understanding and detecting the risk factors for pancreatic cancer represents an important step in the prevention and early diagnosis of this type of neoplasia. This review reports the available evidence on different risk factors and identifies the areas that could benefit the most from additional studies.
引用
收藏
页数:34
相关论文
共 50 条
  • [21] Epidemiology and risk factors for pancreatic cancer
    Lowenfels, AB
    Maisonneuve, P
    BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2006, 20 (02) : 197 - 209
  • [22] Risk and genetic factors in pancreatic cancer
    Gullo, L
    Lowenfels, AB
    Maisonneuve, P
    ITALIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1998, 30 (06): : 587 - 592
  • [23] Environmental factors and risk of pancreatic cancer
    Lowenfels, AB
    Masionneuve, P
    PANCREATOLOGY, 2003, 3 (01) : 1 - 7
  • [24] Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds
    Rulyak, SJ
    Lowenfels, AB
    Maisonneuve, P
    Brentnall, TA
    GASTROENTEROLOGY, 2003, 124 (05) : 1292 - 1299
  • [25] Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds
    Rulyak, SJ
    Lowenfels, AB
    Maisonneuve, P
    Kimmey, MB
    Brentnall, TA
    GASTROENTEROLOGY, 2002, 122 (04) : A494 - A494
  • [26] Risk factors for pancreatic cancer: a summary review of meta-analytical studies
    Maisonneuve, Patrick
    Lowenfels, Albert B.
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2015, 44 (01) : 186 - 198
  • [27] Risk factors for pancreatic cancer in patients with and without a family history of pancreatic cancer
    Humphris, Jeremy
    Johns, Amber
    Simpson, Skye
    Chang, David
    Cowley, Mark J.
    Pajic, Marina
    Jones, Marc
    Simpson, Skye
    Mead, Scott
    Biankin, Andrew
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 : 127 - 127
  • [28] The queensland pancreatic cancer study-identifying risk factors for pancreatic cancer
    Neale, Rachel
    Whiteman, David
    Young, Joanne
    Fritschi, Lin
    Fawcete, Jonathan
    Webbl, Penny
    Risch, Harvey
    PANCREAS, 2008, 36 (02) : 223 - 223
  • [29] Risk factors and therapeutic targets in pancreatic cancer
    Woermann, Sonja Maria
    Alguel, Hana
    FRONTIERS IN ONCOLOGY, 2013, 3
  • [30] Environmental risk factors for pancreatic cancer: an update
    Barone, Elisa
    Corrado, Alda
    Gemignani, Federica
    Landi, Stefano
    ARCHIVES OF TOXICOLOGY, 2016, 90 (11) : 2617 - 2642