A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells

被引:0
|
作者
Lin, L.
Benson Jr, D. M.
DeAngelis, S.
Bakan, C. E.
Li, P. K.
Li, C.
Lin, J.
机构
关键词
D O I
10.1002/ijc.35160
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:E16 / E16
页数:1
相关论文
共 50 条
  • [21] A novel small molecule exhibits potent growth suppressive activity through the inhibition of constitutive JAK2/STAT3 signaling in breast cancer, pancreatic cancer, and glioblastoma cells
    Lin, Li
    Hutzen, Brian
    Ball, Sarah
    Foust, Elizabeth
    DeAngelis, Stephanie
    Zuo, Mingxin
    Peng, Zhengang
    Li, Chenglong
    Fuchs, James
    Li, Pui-Kai
    Lesinski, Gregory B.
    Kulp, Samuel
    Lin, Huey-Jen L.
    Ihnat, Michael A.
    Hoyt, Dale
    Termuhlen, Amanda M.
    Gross, Tom
    Lin, Jiayuh
    CANCER RESEARCH, 2009, 69
  • [22] PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction
    Kato, Masaya
    Muromoto, Ryuta
    Togi, Sumihito
    Iwakami, Masashi
    Kitai, Yuichi
    Kon, Shigeyuki
    Oritani, Kenji
    Matsuda, Tadashi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 461 (02) : 366 - 371
  • [23] NOVEL STAT 3 INHIBITORS FLLL32 AND LLL12 INHIBIT STAT3 PHOSPHORYLATION AND INDUCE APOPTOSIS IN HUMAN OSTEOSARCOMA CELLS
    Onimoe, Grace
    Lin, Li
    Wei, Changching
    Gross, Thomas
    Termuhlen, Amanda
    Lin, Jiayuh
    PEDIATRIC BLOOD & CANCER, 2010, 54 (06) : 843 - 844
  • [24] Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium
    Mitzel, Dana N.
    Jaramillo, Richard J.
    Stout-Delgado, Heather
    Senft, Albert P.
    Harrod, Kevin S.
    JOURNAL OF GENERAL VIROLOGY, 2014, 95 : 26 - 37
  • [25] Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells
    Lee, Mee-Hyun
    Kundu, Joydeb Kumar
    Keum, Young-Sam
    Cho, Yong-Yeon
    Surh, Young-Joon
    Choi, Bu Young
    BIOMOLECULES & THERAPEUTICS, 2014, 22 (05) : 426 - 430
  • [26] STAT3, but not ERK, mediates the IL-6-induced proliferation of renal cancer cells
    Horiguchi, A
    Oya, M
    Marumo, K
    Murai, M
    JOURNAL OF UROLOGY, 2002, 167 (04): : 133 - 133
  • [27] STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells
    Spiotto, MT
    Chung, TDK
    PROSTATE, 2000, 42 (03): : 186 - 195
  • [28] A small molecule STAT3 inhibitor, LLL12, enhances cisplatin- and paclitaxel-mediated inhibition of cell growth and migration in human ovarian cancer cells
    Zhang, Ruijie
    Chen, Xiang
    Fu, Shengling
    Xu, Liang
    Lin, Jiayuh
    ONCOLOGY REPORTS, 2020, 44 (03) : 1224 - 1232
  • [29] Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells
    K Bauer
    A K Kretzschmar
    H Cvijic
    C Blumert
    D Löffler
    K Brocke-Heidrich
    C Schiene-Fischer
    G Fischer
    A Sinz
    C V Clevenger
    F Horn
    Oncogene, 2009, 28 : 2784 - 2795
  • [30] Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells
    Bauer, K.
    Kretzschmar, A. K.
    Cvijic, H.
    Blumert, C.
    Loeffler, D.
    Brocke-Heidrich, K.
    Schiene-Fischer, C.
    Fischer, G.
    Sinz, A.
    Clevenger, C. V.
    Horn, F.
    ONCOGENE, 2009, 28 (31) : 2784 - 2795