NOVEL STAT 3 INHIBITORS FLLL32 AND LLL12 INHIBIT STAT3 PHOSPHORYLATION AND INDUCE APOPTOSIS IN HUMAN OSTEOSARCOMA CELLS

被引：0
|
作者：
Onimoe, Grace [1 ]
Lin, Li [1 ]
Wei, Changching [1 ]
Gross, Thomas [1 ]
Termuhlen, Amanda [1 ]
Lin, Jiayuh [1 ]
机构：
[1] Ohio State Univ, Nationwide Childrens Hosp, Columbus, OH 43210 USA
来源：
PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：843 / 844
页数：2
相关论文
共 50 条
  • [1] Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
    Grace-Ifeyinwa Onimoe
    Aiguo Liu
    Li Lin
    Chang-Ching Wei
    Eric B. Schwartz
    Deepak Bhasin
    Chenglong Li
    James R. Fuchs
    Pui-kai Li
    Peter Houghton
    Amanda Termuhlen
    Thomas Gross
    Jiayuh Lin
    [J]. Investigational New Drugs, 2012, 30 : 916 - 926
  • [2] Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice
    Onimoe, Grace-Ifeyinwa
    Liu, Aiguo
    Lin, Li
    Wei, Chang-Ching
    Schwartz, Eric B.
    Bhasin, Deepak
    Li, Chenglong
    Fuchs, James R.
    Li, Pui-kai
    Houghton, Peter
    Termuhlen, Amanda
    Gross, Thomas
    Lin, Jiayuh
    [J]. INVESTIGATIONAL NEW DRUGS, 2012, 30 (03) : 916 - 926
  • [3] Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells
    Wei, Chang-Ching
    Ball, Sarah
    Lin, Li
    Liu, Aiguo
    Fuchs, James R.
    Li, Pui-Kai
    Li, Chenglong
    Lin, Jiayuh
    [J]. INTERNATIONAL JOURNAL OF ONCOLOGY, 2011, 38 (01) : 279 - 285
  • [4] The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells
    Ball, Sarah
    Li, Chenglong
    Li, Pui-Kai
    Lin, Jiayuh
    [J]. PLOS ONE, 2011, 6 (04):
  • [5] The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines
    Fossey, Stacey L.
    Bear, Misty D.
    Lin, Jiayuh
    Li, Chenglong
    Schwartz, Eric B.
    Li, Pui-Kai
    Fuchs, James R.
    Fenger, Joelle
    Kisseberth, William C.
    London, Cheryl A.
    [J]. BMC CANCER, 2011, 11
  • [6] The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines
    Stacey L Fossey
    Misty D Bear
    Jiayuh Lin
    Chenglong Li
    Eric B Schwartz
    Pui-Kai Li
    James R Fuchs
    Joelle Fenger
    William C Kisseberth
    Cheryl A London
    [J]. BMC Cancer, 11
  • [7] LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy
    Zuo, Mingxin
    Li, Chenglong
    Lin, Jiayuh
    Javle, Milind
    [J]. ONCOTARGET, 2015, 6 (13) : 10940 - 10949
  • [8] Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines
    Couto, Jason I.
    Bear, Misty D.
    Lin, Jiayuh
    Pennel, Michael
    Kulp, Samuel K.
    Kisseberth, William C.
    London, Cheryl A.
    [J]. BMC VETERINARY RESEARCH, 2012, 8
  • [9] LLL12 Inhibits Endogenous and Exogenous Interleukin-6-induced STAT3 Phosphorylation in Human Pancreatic Cancer Cells
    Liu, Aiguo
    Liu, Yan
    Li, Pui-Kai
    Li, Chenglong
    Lin, Jiayuh
    [J]. ANTICANCER RESEARCH, 2011, 31 (06) : 2029 - 2035
  • [10] Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines
    Jason I Couto
    Misty D Bear
    Jiayuh Lin
    Michael Pennel
    Samuel K Kulp
    William C Kisseberth
    Cheryl A London
    [J]. BMC Veterinary Research, 8
12345