The Vital Role of Immunohematology in Diagnosing Paroxysmal Cold Hemoglobinuria: A Clinical Case Report

被引：0

作者：

Gutierrez, Willy Nava ^{[1
,2
]}

Cortes, Paola Villa ^{[3
]}

Morales, Ricardo Ramirez ^{[4
]}

Garza, Juan P. Espinoza ^{[5
]}

Mora, Jaime E. Espinosa ^{[6
]}

机构：

[1] Inst Seguridad & Serv Sociales Trabajadores Estado, Hematol & Oncol, Monterrey, Mexico

[2] Univ Monterrey, Hematol, Monterrey, Mexico

[3] Inst Seguridad & Serv Sociales Trabajadores Estado, Crit Care Med, Monterrey, Mexico

[4] Inst Seguridad & Serv Sociales Trabajadores Estado, Rheumatol, Monterrey, Mexico

[5] Inst Seguridad & Serv Sociales Trabajadores Estado, Pulmonol, Monterrey, Mexico

[6] Inst Seguridad & Serv Sociales Trabajadores Estado, Infect Dis, Monterrey, Mexico

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 09期

关键词：

complement-mediated hemolysis; therapeutic plasma exchange (tpe); rituximab; paroxysmal cold hemoglobinuria (pch); mexico; eculizumab; cold agglutinin disease; autoimmune vasculitis; autoimmune hemolytic anemia (aiha); anca-negative; AUTOIMMUNE HEMOLYTIC-ANEMIA;

D O I：

10.7759/cureus.69362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia caused by the binding of IgG immunoglobulins to red blood cells at cold temperatures, leading to hemolysis upon rewarming. The Donath-Landsteiner test can show biphasic hemolysis, leading to diagnosis. There is no consensus, but chemoimmunotherapy with or without plasma exchange is commonly employed. We present the case of a 42-year-old male who experienced symptoms of hemolysis after cold exposure in a semi-arid, warm-climate city.

引用

页数：6

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