New reactions by pyridoxal phosphate-dependent enzymes

被引：3
|
作者：
Daniel-Ivad, Phillip [1 ]
Ryan, Katherine S. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC, Canada
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 81卷
关键词：
BOND FORMATION; BIOSYNTHESIS; INTERMEDIATE; ACID;
D O I：
10.1016/j.cbpa.2024.102472
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyridoxal phosphate (PLP) is a cofactor that is widely employed in enzymology. This pyridine-containing cofactor can be used for reactions ranging from transaminations to oxidations. The catalytic versatility can be understood by considering the chemical features of this cofactor. In recent years, exciting new reactions involving PLP have been discovered in natural products biosynthesis, upending our understanding of what this cofactor is capable of. Here we review some of the most exciting PLP-dependent reactions from the last five years.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Pyridoxal-5′-phosphate-dependent catalytic antibodies
    Gramatikova, SI
    Christen, P
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2000, 83 (1-3) : 183 - 190
  • [42] Pyridoxal-5′-phosphate-dependent catalytic antibodies
    Gramatikova, S
    Mouratou, B
    Stetefeld, J
    Mehta, PK
    Christen, P
    JOURNAL OF IMMUNOLOGICAL METHODS, 2002, 269 (1-2) : 99 - 110
  • [43] Current Advances on Structure-Function Relationships o Pyridoxal 5′-Phosphate-Dependent Enzymes
    Liang, Jing
    Han, Qian
    Tan, Yang
    Ding, Haizhen
    Li, Jianyong
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2019, 6
  • [44] Pyridoxal-5′-phosphate-dependent catalytic antibodies
    Svetlana I. Gramatikova
    Philipp Christen
    Applied Biochemistry and Biotechnology, 2000, 83 : 183 - 193
  • [45] Biotin synthase is a pyridoxal phosphate-dependent cysteine desulfurase
    Ollagnier-de-Choudens, S
    Mulliez, E
    Hewitson, KS
    Fontecave, M
    BIOCHEMISTRY, 2002, 41 (29) : 9145 - 9152
  • [46] O-PHOSPHORYLETHANOLAMINE AMMONIA LYASE, A NEW PYRIDOXAL PHOSPHATE-DEPENDENT ENZYME
    FLESHOOD, HL
    PITOT, HC
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1969, 36 (01) : 110 - &
  • [47] STABILITY OF SOME PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES IN VITAMIN-B-6 DEFICIENT RATS
    HUNTER, JE
    HARPER, AE
    JOURNAL OF NUTRITION, 1976, 106 (05): : 653 - 664
  • [48] Molecular characterization of novel pyridoxal-5′-phosphate-dependent enzymes from the human microbiome
    Fleischman, Nicholas M.
    Das, Debanu
    Kumar, Abhinav
    Xu, Qingping
    Chiu, Hsiu-Ju
    Jaroszewski, Lukasz
    Knuth, Mark W.
    Klock, Heath E.
    Miller, Mitchell D.
    Elsliger, Marc-Andre
    Godzik, Adam
    Lesley, Scott A.
    Deacon, Ashley M.
    Wilson, Ian A.
    Toney, Michael D.
    PROTEIN SCIENCE, 2014, 23 (08) : 1060 - 1076
  • [49] CLINICAL-SIGNIFICANCE OF AMINO-ACID TRANSFORMATIONS BY THE ACTION OF PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES
    BRAUNSTEIN, AE
    VESTNIK AKADEMII MEDITSINSKIKH NAUK SSSR, 1982, (09): : 3 - 9
  • [50] pH studies on the mechanism of the pyridoxal phosphate-dependent dialkylglycine decarboxylase
    Zhou, XZ
    Toney, MD
    BIOCHEMISTRY, 1999, 38 (01) : 311 - 320
12345