New reactions by pyridoxal phosphate-dependent enzymes

被引：3
|
作者：
Daniel-Ivad, Phillip [1 ]
Ryan, Katherine S. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC, Canada
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 81卷
关键词：
BOND FORMATION; BIOSYNTHESIS; INTERMEDIATE; ACID;
D O I：
10.1016/j.cbpa.2024.102472
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyridoxal phosphate (PLP) is a cofactor that is widely employed in enzymology. This pyridine-containing cofactor can be used for reactions ranging from transaminations to oxidations. The catalytic versatility can be understood by considering the chemical features of this cofactor. In recent years, exciting new reactions involving PLP have been discovered in natural products biosynthesis, upending our understanding of what this cofactor is capable of. Here we review some of the most exciting PLP-dependent reactions from the last five years.
引用
收藏
页数：10
相关论文
共 50 条
  • [31] Pyridoxal 5'-phosphate-dependent catalytic antibody
    Gramatikova, SI
    Christen, P
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (48) : 30583 - 30586
  • [32] A pyridoxal 5′-phosphate-dependent Mannich cyclase
    Jinmin Gao
    Shaonan Liu
    Chen Zhou
    Darwin Lara
    Yike Zou
    Yang Hai
    Nature Catalysis, 2023, 6 : 476 - 486
  • [33] A pyridoxal 5'-phosphate-dependent Mannich cyclase
    Gao, Jinmin
    Liu, Shaonan
    Zhou, Chen
    Lara, Darwin
    Zou, Yike
    Hai, Yang
    NATURE CATALYSIS, 2023, 6 (06) : 476 - +
  • [34] Pyridoxal 5′-Phosphate-Dependent Enzymes at the Crossroads of Host-Microbe Tryptophan Metabolism
    Cellini, Barbara
    Zelante, Teresa
    Dindo, Mirco
    Bellet, Marina M.
    Renga, Giorgia
    Romani, Luigina
    Costantini, Claudio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (16) : 1 - 21
  • [35] Stereochemical constraint in the evolution of pyridoxal-5'-phosphate-dependent enzymes. A hypothesis
    Christen, P
    Kasper, P
    Gehring, H
    Sterk, M
    FEBS LETTERS, 1996, 389 (01) : 12 - 14
  • [36] INDUCTION OF PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES IN VITAMIN-B-6 DEFICIENT RATS
    HUNTER, JE
    HARPER, AE
    JOURNAL OF NUTRITION, 1977, 107 (02): : 235 - 244
  • [37] The structural basis of pyridoxal-5′-phosphate-dependent β-NAD-alkylating enzymes
    Awakawa, Takayoshi
    Mori, Takahiro
    Barra, Lena
    Ahmed, Yusef
    Ushimaru, Richiro
    Gao, Yaojie
    Adachi, Naruhiko
    Senda, Toshiya
    Terada, Tohru
    Tantillo, Dean J.
    Abe, Ikuro
    NATURE CATALYSIS, 2024, 7 (10): : 1099 - 1108
  • [38] Functional properties of immobilized pyridoxal 5′-phosphate-dependent enzymes probed by absorption microspectrophotometry
    Mozzarelli, A
    Campanini, B
    Bettati, S
    Peracchi, A
    BIOCHEMISTRY AND MOLECULAR BIOLOGY OF VITAMIN B6 AND PQQ-DEPENDENT PROTEINS, 2000, : 349 - 354
  • [39] Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes
    Soo, Valerie W. C.
    Yosaatmadja, Yuliana
    Squire, Christopher J.
    Patrick, Wayne M.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (38) : 19873 - 19887
  • [40] PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES OF THE METABOLISM OF SULFUR-CONTAINING AMINO-ACIDS
    GABIBOV, AG
    SHUSTER, AM
    KHOMUTOV, AR
    TOLOSA, EA
    GORYACHENKOVA, EV
    BIOCHEMISTRY-MOSCOW, 1989, 54 (05) : 573 - 576
12345