New reactions by pyridoxal phosphate-dependent enzymes

被引：3
|
作者：
Daniel-Ivad, Phillip [1 ]
Ryan, Katherine S. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC, Canada
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 81卷
关键词：
BOND FORMATION; BIOSYNTHESIS; INTERMEDIATE; ACID;
D O I：
10.1016/j.cbpa.2024.102472
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyridoxal phosphate (PLP) is a cofactor that is widely employed in enzymology. This pyridine-containing cofactor can be used for reactions ranging from transaminations to oxidations. The catalytic versatility can be understood by considering the chemical features of this cofactor. In recent years, exciting new reactions involving PLP have been discovered in natural products biosynthesis, upending our understanding of what this cofactor is capable of. Here we review some of the most exciting PLP-dependent reactions from the last five years.
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页数：10
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