TARGETING CTPS1 AND NUCLEOTIDE BIOSYNTHESIS PATHWAYS AS A NOVEL THERAPEUTIC APPROACH IN MYC-AMPLIFIED MEDULLOBLASTOMA

被引：0
|
作者：
Hathaway, Matthew [1 ]
Jagana, Hawa [1 ]
Terrones, Isabella [1 ]
Miyaki, Aya [1 ]
Hemenway, John [1 ]
Meechan, Michael [1 ]
Gadek, Kate [1 ]
Slusher, Barbara [2 ]
Evans II, Myron [1 ,3 ]
机构：
[1] Seattle Childrens Res Inst, Ben Towne Ctr, Seattle, WA USA
[2] Johns Hopkins Med, Baltimore, MD USA
[3] Univ Washington, Dept Pediat, Seattle, WA USA
来源：
NEURO-ONCOLOGY | 2024年 / 26卷
关键词：
D O I：
10.1093/neuonc/noae064.549
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MDB-101
引用
收藏
页数：1
相关论文
共 50 条
  • [31] PLX51107, A NOVEL BROMODOMAIN INHIBITOR, WORKS SYNERGISTICALLY WITH AURORA-A KINASE INHIBITOR MLN8327 IN TREATING MYC-AMPLIFIED MEDULLOBLASTOMA
    Wadhwa, Elizabeth
    Zhang, Jie
    Powell, Ben
    Van, Cassandra
    Gustafson, Clay
    Nicolaides, Theo
    NEURO-ONCOLOGY, 2017, 19 : 192 - 192
  • [32] STP938, a Novel, Potent and Selective Inhibitor of CTP Synthase 1 (CTPS1) Is a Targeted Therapy Specifically Blocking De Novo Nucleotide Synthesis in Lymphomas and Leukemias
    Parker, Andy
    BLOOD, 2020, 136
  • [33] Targeting aging-associated pathways: a novel therapeutic approach for cancer
    Sharma Y.
    Das A.
    Vegetos, 2024, 37 (1): : 16 - 30
  • [34] A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma
    Kling, Matthew J.
    Kesherwani, Varun
    Mishra, Nitish K.
    Alexander, Gracey
    McIntyre, Erin M.
    Ray, Sutapa
    Challagundla, Kishore B.
    Joshi, Shantaram S.
    Coulter, Don W.
    Chaturvedi, Nagendra K.
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 41 (01)
  • [35] A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma
    Matthew J. Kling
    Varun Kesherwani
    Nitish K. Mishra
    Gracey Alexander
    Erin M. McIntyre
    Sutapa Ray
    Kishore B. Challagundla
    Shantaram S. Joshi
    Don W. Coulter
    Nagendra K. Chaturvedi
    Journal of Experimental & Clinical Cancer Research, 41
  • [36] A Novel Combination Approach Targeting an Enhanced Protein Synthesis Pathway in MYC-driven (Group 3) Medulloblastoma
    Chaturvedi, Nagendra K.
    Kling, Matthew J.
    Griggs, Connor N.
    Kesherwani, Varun
    Shukla, Mamta
    McIntyre, Erin M.
    Ray, Sutapa
    Liu, Yutong
    McGuire, Timothy R.
    Sharp, J. Graham
    Band, Hamid
    Joshi, Shantaram S.
    Coulter, Don W.
    MOLECULAR CANCER THERAPEUTICS, 2020, 19 (06) : 1351 - 1362
  • [37] A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways
    Podar, Klaus
    Anderson, Kenneth C.
    CELL CYCLE, 2010, 9 (09) : 1722 - 1728
  • [38] Targeting DNA repair pathways: A novel approach to reduce cancer therapeutic resistance
    Zhu, Yongjian
    Hu, Jue
    Hu, Yiduo
    Liu, Weiguo
    CANCER TREATMENT REVIEWS, 2009, 35 (07) : 590 - 596
  • [39] Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer
    Chen, Ping
    Hu, Tao
    Liang, Yupei
    Jiang, Yanan
    Pan, Yongfu
    Li, Chunjie
    Zhang, Ping
    Wei, Dongping
    Li, Pei
    Jeong, Lak Shin
    Chu, Yiwei
    Qi, Hui
    Yang, Meng
    Hoffman, Robert M.
    Dong, Ziming
    Jia, Lijun
    ONCOTARGET, 2015, 6 (11) : 9002 - 9017
  • [40] The Therapeutic Potential of Targeting Key Signaling Pathways as a Novel Approach to Ameliorating Post-Surgical Adhesions
    Ensan, Behzad
    Bathaei, Parsa
    Nassiri, Mohammadreza
    Khazaei, Majid
    Hassanian, Seyed Mahdi
    Abdollahi, Abbas
    Ghorbani, Hamid Reza
    Aliakbarian, Mohsen
    Ferns, Gordon A.
    Avan, Amir
    CURRENT PHARMACEUTICAL DESIGN, 2022, 28 (45) : 3592 - 3617
12345