TARGETING CTPS1 AND NUCLEOTIDE BIOSYNTHESIS PATHWAYS AS A NOVEL THERAPEUTIC APPROACH IN MYC-AMPLIFIED MEDULLOBLASTOMA

被引：0
|
作者：
Hathaway, Matthew [1 ]
Jagana, Hawa [1 ]
Terrones, Isabella [1 ]
Miyaki, Aya [1 ]
Hemenway, John [1 ]
Meechan, Michael [1 ]
Gadek, Kate [1 ]
Slusher, Barbara [2 ]
Evans II, Myron [1 ,3 ]
机构：
[1] Seattle Childrens Res Inst, Ben Towne Ctr, Seattle, WA USA
[2] Johns Hopkins Med, Baltimore, MD USA
[3] Univ Washington, Dept Pediat, Seattle, WA USA
来源：
NEURO-ONCOLOGY | 2024年 / 26卷
关键词：
D O I：
10.1093/neuonc/noae064.549
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MDB-101
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line
    Henderson, Jacob J.
    Wagner, Jacob P.
    Hofmann, Nicolle E.
    Eide, Christopher A.
    Cho, Yoon-Jae
    Druker, Brian J.
    Davare, Monika A.
    PEDIATRIC BLOOD & CANCER, 2017, 64 (10)
  • [22] Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways
    Pham, Khoa
    Hanaford, Allison R.
    Poore, Brad A.
    Maxwell, Micah J.
    Sweeney, Heather
    Parthasarathy, Akhila
    Alt, Jesse
    Rais, Rana
    Slusher, Barbara S.
    Eberhart, Charles G.
    Raabe, Eric H.
    CANCERS, 2022, 14 (05)
  • [23] Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells
    Valinciute, Gintvile
    Ecker, Jonas
    Selt, Florian
    Hielscher, Thomas
    Sigaud, Romain
    Ridinger, Johannes
    Thatikonda, Venu
    Gatzweiler, Charlotte
    Robinson, Sarah
    Talbot, Julie
    Bernardi, Flavia
    Picard, Daniel
    Blattner-Johnson, Mirjam
    Schmid, Simone
    Jones, David T.
    van Tilburg, Cornelis M.
    Capper, David
    Kool, Marcel
    Remke, Marc
    Oehme, Ina
    Pfister, Stefan M.
    Roussel, Martine F.
    Ayrault, Olivier
    Witt, Olaf
    Milde, Till
    JOURNAL OF NEURO-ONCOLOGY, 2023, 163 (01) : 143 - 158
  • [24] Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells
    Gintvile Valinciute
    Jonas Ecker
    Florian Selt
    Thomas Hielscher
    Romain Sigaud
    Johannes Ridinger
    Venu Thatikonda
    Charlotte Gatzweiler
    Sarah Robinson
    Julie Talbot
    Flavia Bernardi
    Daniel Picard
    Mirjam Blattner-Johnson
    Simone Schmid
    David T. Jones
    Cornelis M. van Tilburg
    David Capper
    Marcel Kool
    Marc Remke
    Ina Oehme
    Stefan M. Pfister
    Martine F. Roussel
    Olivier Ayrault
    Olaf Witt
    Till Milde
    Journal of Neuro-Oncology, 2023, 163 : 143 - 158
  • [25] CTPS1 Is a Novel Therapeutic Target in Multiple Myeloma That Synergizes with Inhibition of ATR, CHEK1 or WEE1
    Pfeiffer, Christina
    Grandits, Alexander Michael
    Asnagli, Helene
    Schneller, Anja
    Huber, Julia
    Zojer, Niklas
    Schreder, Martin
    Parker, Andrew
    Bolomsky, Arnold
    Beer, Philip
    Ludwig, Heinz
    BLOOD, 2022, 140 : 7088 - 7089
  • [26] CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1
    Pfeiffer, Christina
    Grandits, Alexander M.
    Asnagli, Helene
    Schneller, Anja
    Huber, Julia
    Zojer, Niklas
    Schreder, Martin
    Parker, Andrew E.
    Bolomsky, Arnold
    Beer, Philip A.
    Ludwig, Heinz
    LEUKEMIA, 2024, 38 (01) : 181 - 192
  • [27] CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1
    Christina Pfeiffer
    Alexander M. Grandits
    Hélène Asnagli
    Anja Schneller
    Julia Huber
    Niklas Zojer
    Martin Schreder
    Andrew E. Parker
    Arnold Bolomsky
    Philip A. Beer
    Heinz Ludwig
    Leukemia, 2024, 38 : 181 - 192
  • [28] SYNERGISTIC EFFICACY OF Y BOX BINDING PROTEIN 1 (YBX1) INHIBITION COMBINED WITH CHEMOTHERAPY FOR THE TREATMENT OF MYC-AMPLIFIED MEDULLOBLASTOMA
    Carney, Stephen
    Bonatto, Christian
    Guadarrama, Guadalupe
    Tailor, Dhanir
    Malhotra, Sanjay
    Evans, Myron, II
    NEURO-ONCOLOGY, 2023, 25
  • [29] mTORC2/Akt SIGNALING IS MODULATED BY NONCANONICAL MITOCHONDRIAL Notch1/PINK1 INTERACTION IN myc-AMPLIFIED MEDULLOBLASTOMA TUMORIGENESIS
    Feroze, Abdullah
    Lee, Kyu-Sun
    Gholamin, Sharareh
    Wu, Zhihao
    Lu, Bingwei
    Mitra, Siddhartha
    Cheshier, Samuel
    NEURO-ONCOLOGY, 2014, 16 : 71 - 72
  • [30] mTORC2/Akt signaling is modulated by noncanonical mitochondrial Notch1/PINK1 interaction in myc-amplified medulloblastoma tumorigenesis
    Feroze, Abdullah H. y
    Lee, Kyu-Sun
    Gholamin, Sharareh
    Wu, Zhihao
    Weissman, Irving
    Lu, Bingwei
    Mitra, Siddhartha S.
    Cheshier, Samuel
    CANCER RESEARCH, 2014, 74 (19)
12345