Long-term 3D primary epithelioid cultures reveal genes that regulate esophageal cell fitness

被引：0

作者：

Jones, Philip H. ^{[1
]}

机构：

[1] Wellcome Sanger Inst, Hinxton, England

来源：

NATURE GENETICS | 2024年 / 56卷 / 10期

关键词：

D O I：

10.1038/s41588-024-01887-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Primary cell cultures need to be frequently passaged, which limits the study of long-term biological processes, such as how mutant clones colonize aging epithelia. Esophageal epithelioids self-maintain for months, recapitulating progenitor cell behavior in vivo. Epithelioid CRISPR-Cas9 screens reveal genes encoding molecules that control cell fitness.

引用

页码：2010 / 2011

页数：2

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