Long-term 3D primary epithelioid cultures reveal genes that regulate esophageal cell fitness

被引：0
|
作者：
Jones, Philip H. [1 ]
机构：
[1] Wellcome Sanger Inst, Hinxton, England
来源：
NATURE GENETICS | 2024年 / 56卷 / 10期
关键词：
D O I：
10.1038/s41588-024-01887-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Primary cell cultures need to be frequently passaged, which limits the study of long-term biological processes, such as how mutant clones colonize aging epithelia. Esophageal epithelioids self-maintain for months, recapitulating progenitor cell behavior in vivo. Epithelioid CRISPR-Cas9 screens reveal genes encoding molecules that control cell fitness.
引用
收藏
页码：2010 / 2011
页数：2
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