Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis

被引：0
|
作者：
Luo, Longlong [1 ,2 ]
Cheng, Huaitao [3 ]
Liu, Zhuang [4 ]
Olszewski, Pawel [1 ]
Pasquali, Lorenzo [4 ]
Xu, Ning [4 ]
Enge, Martin [3 ]
Pivarcsi, Andor [1 ]
Sonkoly, Eniko [1 ,2 ]
机构：
[1] Uppsala Univ, Dept Med Biochem & Microbiol IMBIM, Uppsala, Sweden
[2] Uppsala Univ, Dept Med Sci, Dermatol & Venereol, Uppsala, Sweden
[3] Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden
[4] Karolinska Inst, Dept Med Solna, Dermatol & Venereol Div, Stockholm, Sweden
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1093/bjd/ljae210
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Our study unveils the cellular and molecular dynamics in psoriasis epidermis, revealing diverse cell states and their interactions driving inflammation and altered developmental trajectories. Importantly, a previously overlooked plasmacytoid dendritic cell cluster with inflammatory properties was identified in the epidermis of chronic psoriasis lesions, suggesting a potential role for these cells in chronic psoriasis.
引用
收藏
页码：635 / 637
页数：3
相关论文
共 50 条
  • [41] Single-cell analysis of granulocytes infiltrating gastrointestinal cancer
    Sasagawa, Shota
    Honma, Yoshitaka
    Peng, Xinxin
    Maejima, Kazuhiro
    Nagaoka, Koji
    Kobayashi, Yukari
    Oosawa, Ayako
    Johnson, Todd
    Okawa, Yuki
    Liang, Han
    Kakimi, Kazuhiro
    Yamada, Yasuhide
    CANCER SCIENCE, 2025, 116 : 1322 - 1322
  • [42] Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells
    Yang, Y.
    Alves, T.
    Miao, M. Z.
    Wu, Y. C.
    Li, G.
    Lou, J.
    Hasturk, H.
    Van Dyke, T. E.
    Kantarci, A.
    Wu, D.
    JOURNAL OF DENTAL RESEARCH, 2024, 103 (01) : 71 - 80
  • [43] Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells
    Zhang, Chen
    Han, Xueshuai
    Liu, Jingkun
    Chen, Lei
    Lei, Ying
    Chen, Kunying
    Si, Jia
    Wang, Tian-yi
    Zhou, Hui
    Zhao, Xiaoyun
    Zhang, Xiaohui
    An, Yihua
    Li, Yueying
    Wang, Qian-Fei
    GENOMICS PROTEOMICS & BIOINFORMATICS, 2022, 20 (01) : 70 - 86
  • [44] Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells
    Gou, Bo
    Chu, Xiaojing
    Xiao, Yi
    Liu, Pinxuan
    Zhang, Hao
    Gao, Zeyu
    Song, Moshi
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
  • [45] Single-cell transcriptomic signature of paradoxical eczema in patients with psoriasis treated with biologics
    Al-Janabi, Ali
    Martin, Paul
    Simpson, Catherine
    Rhys, Hefin
    Khan, Adnan
    Eyre, Steve
    Christofi, Maria
    Foulkes, Amy
    Skelton, Andrew
    Viatte, Sebastien
    Barton, Anne
    Morris, Andrew
    Smith, Catherine
    Griffiths, Christopher
    Warren, Richard
    BRITISH JOURNAL OF DERMATOLOGY, 2024, 190 (06) : e71 - e71
  • [46] Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis
    Kaur, Japneet
    Adhikari, Manish
    Sabol, Hayley M.
    Anloague, Aric
    Khan, Sharmin
    Kurihara, Noriyoshi
    Diaz-delCastillo, Marta
    Andreasen, Christina Moller
    Barnes, Charles Lowry
    Stambough, Jeffrey B.
    Palmieri, Michela
    Reyes-Castro, Olivia
    Zarrer, Jennifer
    Taipaleenmaeki, Hanna
    Ambrogini, Elena
    Almeida, Maria
    O'Brien, Charles A.
    Nookaw, Intawat
    Delgado-Calle, Jesus
    CANCER RESEARCH, 2024, 84 (23) : 3936 - 3952
  • [47] Single-cell transcriptomic analysis of honeybee brains identifies vitellogenin as caste differentiation-related factor
    Zhang, Wenxin
    Wang, Liangliang
    Zhao, Yinjiao
    Wang, Yufei
    Chen, Chaoyang
    Hu, Yu
    Zhu, Yuanxiang
    Sun, Hao
    Cheng, Ying
    Sun, Qinmiao
    Zhang, Jian
    Chen, Dahua
    ISCIENCE, 2022, 25 (07)
  • [48] Single-cell Transcriptomic Analysis identifies no cellular heterogeneity in GP FoxA2+LTSSC population
    Kumar, Shreya
    Muruganandan, Shanmugam
    Sekar, Shobana
    Pierce, Rachel
    Alberico, Hannah
    Woods, Dori
    Ionescu, Andreia
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 307 - 307
  • [49] Single-cell transcriptomic analysis of Alzheimer's disease
    Mathys, Hansruedi
    Davila-Velderrain, Jose
    Peng, Zhuyu
    Gao, Fan
    Mohammadi, Shahin
    Young, Jennie Z.
    Menon, Madhvi
    He, Liang
    Abdurrob, Fatema
    Jiang, Xueqiao
    Martorell, Anthony J.
    Ransohoff, Richard M.
    Hafler, Brian P.
    Bennett, David A.
    Kellis, Manolis
    Tsai, Li-Huei
    NATURE, 2019, 570 (7761) : 332 - +
  • [50] Single-cell transcriptomic analysis of mouse neocortical development
    Loo, Lipin
    Simon, Jeremy M.
    Xing, Lei
    McCoy, Eric S.
    Niehaus, Jesse K.
    Guo, Jiami
    Anton, E. S.
    Zylka, Mark J.
    NATURE COMMUNICATIONS, 2019, 10 (1)
12345