Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis

被引：0

作者：

Luo, Longlong ^{[1
,2
]}

Cheng, Huaitao ^{[3
]}

Liu, Zhuang ^{[4
]}

Olszewski, Pawel ^{[1
]}

Pasquali, Lorenzo ^{[4
]}

Xu, Ning ^{[4
]}

Enge, Martin ^{[3
]}

Pivarcsi, Andor ^{[1
]}

Sonkoly, Eniko ^{[1
,2
]}

机构：

[1] Uppsala Univ, Dept Med Biochem & Microbiol IMBIM, Uppsala, Sweden

[2] Uppsala Univ, Dept Med Sci, Dermatol & Venereol, Uppsala, Sweden

[3] Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden

[4] Karolinska Inst, Dept Med Solna, Dermatol & Venereol Div, Stockholm, Sweden

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/bjd/ljae210

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Our study unveils the cellular and molecular dynamics in psoriasis epidermis, revealing diverse cell states and their interactions driving inflammation and altered developmental trajectories. Importantly, a previously overlooked plasmacytoid dendritic cell cluster with inflammatory properties was identified in the epidermis of chronic psoriasis lesions, suggesting a potential role for these cells in chronic psoriasis.

引用

页码：635 / 637

页数：3

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