Ironing out obesity

被引：1

作者：

de Souza, Gabriel O. ^{[1
]}

dos Santos, Willian O. ^{[1
]}

Donato, Jose ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2024年 / 35卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

DONATION;

D O I：

10.1016/j.tem.2024.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is associated with dysfunctions in hypothalamic neurons that regulate metabolism, including agouti-related protein (AgRP)-expressing neurons. In a recent article, Zhang et al. demonstrated that either dietor genetically induced obesity promoted iron accumulation specifically in AgRP neurons. Preventing iron overload in AgRP neurons mitigated diet-induced obesity and related comorbidities in male mice.

引用

页码：456 / 458

页数：3

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