Design, synthesis and biological evaluation of isoxazole bearing 1, 3-oxazole-1, 3, 4-oxadiazole derivatives as anticancer agents

被引：2
|
作者：
Lingala, Arun Kumar [1 ,2 ]
Murahari, Kiran Kumar [1 ]
Desireddi, Janardana Reddi [1 ,2 ]
Mothe, Thirupathi [1 ,2 ]
Maiti, Bhimcharan [1 ]
Manchal, Ravinder [2 ]
机构：
[1] Aragen Life Sci Pvt Ltd, Previously known GVK Biosci Pvt Ltd, Med Chem Div, 28A,IDA Nacharam, Hyderabad 500076, India
[2] Chaitanya, Dept Chem, Warangal 506001, India
来源：
CHEMICAL DATA COLLECTIONS | 2023年 / 43卷
关键词：
Zibotentan; Luminespib; 1; 3; 4-oxadiazole; Isoxazole and anticancer; IN-VITRO; ANTIOXIDANT;
D O I：
10.1016/j.cdc.2022.100959
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new library of diverse isoxazole contained 1,3-oxazole-1,3,4-oxadiazole heterocyclic hybrids have been synthesized (9a-j). The compounds were characterized by 1HNMR, 13CNMR & mass spectral data. Further, all derivatives were examined for their preliminary anticancer effects towards prostate cancer (PC3 and DU-145), lung cancer (A549) and breast cancer (MCF-7) human cancer cell lines by employing MTT method. The well-known clinical utilizing drug candidate as etoposide used as standard reference. All the tested compounds displayed moderate to good anticancer activity. Among them, four compounds 9a, 9b, 9c and 9 g possessed most promising activity than etoposide.
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页数：7
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