Boosting macrophage-specific BCAA oxidation enhances immune activation within the tumor microenvironment and diminishes tumor growth in pancreatic cancer

被引：0
|
作者：
Mirji, Gauri
Bhat, Sajad Ahmad
Schug, Zachary
Stanger, Ben Z.
Arany, Zoltan
Shinde, Rahul S.
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-6627
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
6627
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer
    Rucki, Agnieszka A.
    Foley, Kelly
    Zhang, Pingbo
    Xiao, Qian
    Kleponis, Jennifer
    Wu, Annie A.
    Sharma, Rajni
    Mo, Guanglan
    Liu, Angen
    Van Eyk, Jennifer
    Jaffee, Elizabeth M.
    Zheng, Lei
    CANCER RESEARCH, 2017, 77 (01) : 41 - 52
  • [32] Therapeutic Strategies Toward Lactate Dehydrogenase Within the Tumor Microenvironment of Pancreatic Cancer
    Moir, John A. G.
    Long, Anna
    Haugk, Beate
    French, Jeremy J.
    Charnley, Richard M.
    Manas, Derek M.
    Wedge, Steve R.
    Mann, Jelena
    Robinson, Stuart M.
    White, Steve A.
    PANCREAS, 2020, 49 (10) : 1364 - 1371
  • [33] The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers
    Tsunedomi, Ryouichi
    Shindo, Yoshitaro
    Nakajima, Masao
    Yoshimura, Kiyoshi
    Nagano, Hiroaki
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023, 23 (12) : 1121 - 1134
  • [34] KRAS mutations have distinct effects on the tumor immune microenvironment in pancreatic cancer
    Wenger, Andrew
    Baron, Tal
    Vega-Perez, Adrian
    Sisso, Whitney
    Zafra, Maria Paz
    Dow, Lukas
    Siolas, Despina
    CANCER IMMUNOLOGY RESEARCH, 2024, 12 (10)
  • [35] Radiation-mediated complement alternative pathway activation within the lung tumor microenvironment diminishes the efficacy of therapy
    Shah, Harendra
    Saikia, Minakshi
    Wu, Xiaobo
    Atkinson, John
    Hallahan, Dennis
    Singh, Abhay
    Kapoor, Vaishali
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 234 - 234
  • [36] HIFU induces reprogramming of the tumor immune microenvironment in a pancreatic cancer mouse model
    Yamaguchi, Toshihiro
    Kitahara, Shuji
    Matsui, Aya
    Okamoto, Jun
    Muragaki, Yoshihiro
    Masamune, Ken
    MEDICAL MOLECULAR MORPHOLOGY, 2025,
  • [37] Remodeling of Tumor Microenvironment by Tumor-Targeting Nanozymes Enhances Immune Activation of CAR T Cells for Combination Therapy
    Zhu, Lipeng
    Liu, Jie
    Zhou, Guangyu
    Liu, Tzu-Ming
    Dai, Yunlu
    Nie, Guangjun
    Zhao, Qi
    SMALL, 2021, 17 (43)
  • [38] Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer
    Liu, Bingyan
    Jia, Yiping
    Ma, Jun
    Wu, Shaoqiu
    Jiang, Haosheng
    Cao, Yan
    Sun, Xianjun
    Yin, Xiang
    Yan, Shuo
    Shang, Mingyi
    Mao, Aiwu
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2016, 48 (12) : 1067 - 1074
  • [39] PILOCYTIC ASTROCYTOMAS SHOW EVIDENCE OF INTRINSIC IMMUNE SURVEILLANCE AND ACTIVATION WITHIN THE TUMOR MICROENVIRONMENT
    Najem, Hinda
    Tripathi, Shashwat
    McCortney, Kathleen
    Horak, Victoria Jane
    Leonard, Kaethe
    Steffens, Alicia
    Walshon, Jordain
    Horbinski, Craig M.
    Wadhwani, Nitin R.
    James, Charles David
    Lam, Sandi
    Lesniak, Maciej S.
    Burks, Jared K.
    Heimberger, Amy B.
    DeCuypere, Michael G.
    NEURO-ONCOLOGY, 2023, 25
  • [40] Characterization of novel immune checkpoint receptors within the breast cancer tumor microenvironment
    Williams, Austin D.
    Campbell, Jean S.
    Aicher, Lauri D.
    Payne, Kyle K.
    Conejo-Garcia, Jose R.
    Pierce, Robert H.
    Tchou, Julia
    CANCER RESEARCH, 2018, 78 (13)
12345