Boosting macrophage-specific BCAA oxidation enhances immune activation within the tumor microenvironment and diminishes tumor growth in pancreatic cancer

被引:0
|
作者
Mirji, Gauri
Bhat, Sajad Ahmad
Schug, Zachary
Stanger, Ben Z.
Arany, Zoltan
Shinde, Rahul S.
机构
关键词
D O I
10.1158/1538-7445.AM2024-6627
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
6627
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Understanding the immune landscape and tumor microenvironment of pancreatic cancer to improve immunotherapy
    Torphy, Robert J.
    Schulick, Richard D.
    Zhu, Yuwen
    MOLECULAR CARCINOGENESIS, 2020, 59 (07) : 775 - 782
  • [22] Histotripsy Ablation Alters the Tumor Microenvironment and Promotes Immune System Activation in a Subcutaneous Model of Pancreatic Cancer
    Hendricks-Wenger, Alissa
    Sereno, Jacqueline
    Gannon, Jessica
    Zeher, Allison
    Brock, Rebecca M.
    Beitel-White, Natalie
    Simon, Alexander
    Davalos, Rafael, V
    Coutermarsh-Ott, Sheryl
    Vlaisavljevich, Eli
    Allen, Irving Coy
    IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 2021, 68 (09) : 2987 - 3000
  • [23] Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer
    Falcomata, Chiara
    Baerthel, Stefanie
    Schneider, Guenter
    Rad, Roland
    Schmidt-Supprian, Marc
    Saur, Dieter
    CANCER DISCOVERY, 2023, 13 (02) : 278 - 297
  • [24] Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment
    Zhang, Fenghua
    Huang, Bo
    Utturkar, Sagar M.
    Luo, Weichuan
    Cresswell, Gregory
    Herr, Seth A.
    Zheng, Suilan
    Napoleon, John V.
    Jiang, Rina
    Zhang, Boning
    Liu, Muyi
    Lanman, Nadia
    Srinivasarao, Madduri
    Ratliff, Timothy L.
    Low, Philip S.
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [25] Immune responses against cancer stem cell-specific tumor antigens and tumor microenvironment
    Torigoe, Toshihiko
    Hirohashi, Yoshihiko
    Morita, Reina
    Nishizawa, Satoshi
    Yasuda, Kazuyo
    Takahashi, Akari
    Tamura, Yasuaki
    Sato, Noriyuki
    CANCER RESEARCH, 2012, 72
  • [26] Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer
    Li, Jinyang
    Yuan, Salina
    Norgard, Robert J.
    Yan, Fangxue
    Sun, Yu H.
    Kim, Il-Kyu
    Merrell, Allyson J.
    Sela, Yogev
    Jiang, Yanqing
    Bhanu, Natarajan, V
    Garcia, Benjamin A.
    Vonderheide, Robert H.
    Blanco, Andres
    Stanger, Ben Z.
    CANCER DISCOVERY, 2021, 11 (03) : 736 - 753
  • [27] Mapping the molecular communication within the tumor microenvironment of pancreatic cancer as well as between tumor and peritumoral tissue
    Alhamdani, Mohamed S.
    Bauer, Andrea S.
    Hoheisel, Joerg D.
    CANCER RESEARCH, 2017, 77
  • [28] Pancreatic Cancer Requires HSP70 in the Tumor Microenvironment for Cancer Growth
    Giri, Bhuwan
    Garg, Bharti
    Sethi, Vrishketan
    Modi, Shrey
    Banerjee, Sulagna
    Ramakrishnan, Sundaram
    Saluja, Ashok
    Dudeja, Vikas
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2017, 225 (04) : E124 - E125
  • [29] Salinomycin nanoparticles interfere with tumor cell growth and the tumor microenvironment in an orthotopic model of pancreatic cancer
    Daman, Zahra
    Faghihi, Homa
    Montazeri, Hamed
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2018, 44 (09) : 1434 - 1442
  • [30] Tumor microenvironment in pancreatic cancer (PDAC): interplay between tumor cells, stromal cells and immune cells
    Karamitopoulou, Eva
    Wartenberg, Martin
    Galvan, Jose A.
    Zlobec, Inti
    Lugli, Alessandro
    Perren, Aurel
    CANCER RESEARCH, 2015, 75