Macrocycle-Based Supramolecular Drug Delivery Systems: A Concise Review

被引：0
|
作者：
Yang, Yanrui [1 ]
Li, Pengcheng [1 ]
Feng, Haibo [2 ]
Zeng, Rui [1 ]
Li, Shanshan [1 ]
Zhang, Qixiong [3 ,4 ,5 ,6 ]
机构：
[1] Southwest Minzu Univ, Coll Pharm, Key Lab Res & Applicat Ethn Med Proc & Preparat Qi, Chengdu 610041, Peoples R China
[2] Southwest Minzu Univ, Coll Anim Husb & Vet Med, Chengdu 610041, Peoples R China
[3] Sichuan Acad Med Sci, Dept Pharm, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu 610072, Peoples R China
[5] Chuandong Hosp, Sichuan Prov Peoples Hosp, Dept Pharm, Dazhou 635000, Peoples R China
[6] Dazhou First Peoples Hosp, Dazhou 635000, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 16期
基金：
中国国家自然科学基金;
关键词：
macrocyclic compounds; host-guest interaction; supramolecular chemistry; drug delivery systems; bioavailability; NANOSTRUCTURED LIPID CARRIERS; IN-VIVO EVALUATION; BETA-CYCLODEXTRIN; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; MOLECULAR-RECOGNITION; POLYMERIC MICELLES; TARGETED TREATMENT; SKIN PERMEATION; RELEASE; VITRO;
D O I：
10.3390/molecules29163828
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Efficient delivery of therapeutic agents to the lesion site or specific cells is an important way to achieve "toxicity reduction and efficacy enhancement". Macrocycles have always provided many novel ideas for drug or gene loading and delivery processes. Specifically, macrocycles represented by crown ethers, cyclodextrins, cucurbit[n]urils, calix[n]arenes, and pillar[n]arenes have unique properties, which are different cavity structures, good biocompatibility, and good stability. Benefited from these diverse properties, a variety of supramolecular drug delivery systems can be designed and constructed to effectively improve the physical and chemical properties of guest molecules as needed. This review provides an outlook on the current application status and main limitations of macrocycles in supramolecular drug delivery systems.
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页数：32
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