Macrocycle-Based Supramolecular Drug Delivery Systems: A Concise Review

被引：0
|
作者：
Yang, Yanrui [1 ]
Li, Pengcheng [1 ]
Feng, Haibo [2 ]
Zeng, Rui [1 ]
Li, Shanshan [1 ]
Zhang, Qixiong [3 ,4 ,5 ,6 ]
机构：
[1] Southwest Minzu Univ, Coll Pharm, Key Lab Res & Applicat Ethn Med Proc & Preparat Qi, Chengdu 610041, Peoples R China
[2] Southwest Minzu Univ, Coll Anim Husb & Vet Med, Chengdu 610041, Peoples R China
[3] Sichuan Acad Med Sci, Dept Pharm, Personalized Drug Therapy Key Lab Sichuan Prov, Chengdu 610072, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu 610072, Peoples R China
[5] Chuandong Hosp, Sichuan Prov Peoples Hosp, Dept Pharm, Dazhou 635000, Peoples R China
[6] Dazhou First Peoples Hosp, Dazhou 635000, Peoples R China
来源：
MOLECULES | 2024年 / 29卷 / 16期
基金：
中国国家自然科学基金;
关键词：
macrocyclic compounds; host-guest interaction; supramolecular chemistry; drug delivery systems; bioavailability; NANOSTRUCTURED LIPID CARRIERS; IN-VIVO EVALUATION; BETA-CYCLODEXTRIN; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; MOLECULAR-RECOGNITION; POLYMERIC MICELLES; TARGETED TREATMENT; SKIN PERMEATION; RELEASE; VITRO;
D O I：
10.3390/molecules29163828
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Efficient delivery of therapeutic agents to the lesion site or specific cells is an important way to achieve "toxicity reduction and efficacy enhancement". Macrocycles have always provided many novel ideas for drug or gene loading and delivery processes. Specifically, macrocycles represented by crown ethers, cyclodextrins, cucurbit[n]urils, calix[n]arenes, and pillar[n]arenes have unique properties, which are different cavity structures, good biocompatibility, and good stability. Benefited from these diverse properties, a variety of supramolecular drug delivery systems can be designed and constructed to effectively improve the physical and chemical properties of guest molecules as needed. This review provides an outlook on the current application status and main limitations of macrocycles in supramolecular drug delivery systems.
引用
收藏
页数：32
相关论文
共 50 条
  • [31] Anion extractants constructed by macrocycle-based anion recognition
    Zhang, Qunzheng
    Zhou, Yuhao
    Ahmed, Mehroz
    Khashab, Niveen M.
    Han, Weiwei
    Wang, Hu
    Page, Zachariah A.
    Sessler, Jonathan L.
    JOURNAL OF MATERIALS CHEMISTRY A, 2022, 10 (29) : 15297 - 15308
  • [32] Selective sensing of citrate with a macrocycle-based dinuclear receptor
    Hasan, Mohammad
    Rhaman, Md Mhahabubur
    Alamgirl, Azmain
    Tandon, Ritesh
    Hossain, Alamgir
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [33] Facile construction of macrocycle-based dendritic systems: An approach towards nanomaterial and bioengineering.
    Gao, J
    Zingaro, RA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U448 - U448
  • [34] Triggered Enzymatic Biodegradable Drug Delivery Systems Based on Supramolecular Micelles
    Li, Jiajing
    Li, Jun
    5TH EUROPEAN CONFERENCE OF THE INTERNATIONAL FEDERATION FOR MEDICAL AND BIOLOGICAL ENGINEERING, PTS 1 AND 2, 2012, 37 : 1074 - 1077
  • [35] Pulmonary drug delivery strategies: A concise, systematic review
    Patil, J. S.
    Sarasija, S.
    LUNG INDIA, 2012, 29 (01) : 44 - 49
  • [36] Supramolecular hybrid nanomaterials as drug delivery systems
    Adeli, Mohsen
    Hakimpour, Farahman
    Sagvand, Massoumeh
    Jaafari, Mahmoud R.
    Kabiri, Roya
    Moshari, Zahra
    SUPRAMOLECULAR CHEMISTRY, 2011, 23 (06) : 411 - 418
  • [37] Intra-arterial drug delivery - A concise review
    Joshi, Shailendra
    Emala, Charles W.
    Pile-Spellman, John
    JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2007, 19 (02) : 111 - 119
  • [38] Research Progress of Tetralactam Macrocycle-Based Molecular Recognition and Applications
    Guo, Jing
    Li, Shiyao
    Yao, Huan
    Yang, Liupan
    Wang, Lili
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 44 (06) : 1777 - 1785
  • [39] Macrocycle-Based Liquid Crystals: A Study of Topological Effects on Mesomorphism
    Baranoff, Etienne D.
    Voignier, Julie
    Yasuda, Takuma
    Heitz, Valerie
    Sauvage, Jean-Pierre
    Kato, Takashi
    MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2009, 509 : 907 - 914
  • [40] Two sides to supramolecular drug delivery systems
    Hu, Xiao-Yu
    Wang, Leyong
    SUPRAMOLECULAR CHEMISTRY, 2018, 30 (08) : 664 - 666
12345