Association of histone modification with the development of schizophrenia

被引：0
|
作者：
Chen, Yun-zhou [1 ,2 ,3 ]
Zhu, Xiu-mei [1 ,2 ,3 ]
Lv, Peng [1 ,2 ,3 ]
Hou, Xi-kai [1 ,2 ,3 ]
Pan, Ying [1 ,2 ,3 ]
Li, Ang [1 ,2 ,3 ]
Du, Zhe [1 ,2 ,3 ]
Xuan, Jin-feng [1 ,2 ,3 ]
Guo, Xiaochong [4 ]
Xing, Jia-xin [1 ,2 ,3 ,6 ]
Liu, Kun [5 ,6 ]
Yao, Jun [1 ,2 ,3 ,6 ]
机构：
[1] China Med Univ, Sch Forens Med, Shenyang, Peoples R China
[2] Key Lab Forens Bioevidence Sci, Shenyang, Liaoning, Peoples R China
[3] China Med Univ, Ctr Forens Invest, Shenyang, Peoples R China
[4] China Med Univ, Lab Anim Ctr, Shenyang, Peoples R China
[5] China Med Univ, Shengjing Hosp, Key Lab Hlth, Minist Congenital Malformat, Shenyang, Peoples R China
[6] China Med Univ, 77 Puhe Rd, Shenyang 110122, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 175卷
关键词：
Schizophrenia; Histone modification; Chromatin remodeling; Transcriptional regulation; MITOSIS-SPECIFIC PHOSPHORYLATION; DORSOLATERAL PREFRONTAL CORTEX; E3 UBIQUITIN LIGASE; H3; PHOSPHORYLATION; EPIGENETIC MECHANISMS; MEMORY FORMATION; GENE-EXPRESSION; AURORA-B; DEPHOSPHORYLATES GAMMA-H2AX; CHROMATIN MODIFICATIONS;
D O I：
10.1016/j.biopha.2024.116747
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Schizophrenia, influenced by genetic and environmental factors, may involve epigenetic alterations, notably histone modifications, in its pathogenesis. This review summarizes various histone modifications including acetylation, methylation, phosphorylation, ubiquitination, serotonylation, lactylation, palmitoylation, and dopaminylation, and their implications in schizophrenia. Current research predominantly focuses on histone acetylation and methylation, though other modifications also play significant roles. These modifications are crucial in regulating transcription through chromatin remodeling, which is vital for understanding schizophrenia's development. For instance, histone acetylation enhances transcriptional efficiency by loosening chromatin, while increased histone methyltransferase activity on H3K9 and altered histone phosphorylation, which reduces DNA affinity and destabilizes chromatin structure, are significant markers of schizophrenia.
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页数：11
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