Histone lysine methylation: an epigenetic modification?

被引：17

作者：

Blackledge, Neil P. ^{[1
]}

Klose, Robert J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

来源：

EPIGENOMICS | 2010年 / 2卷 / 01期

基金：

英国惠康基金;

关键词：

chromatin; epigenetics; heritable; histone; lysine; methylation; X-CHROMOSOME INACTIVATION; DNA METHYLATION; METHYLTRANSFERASE ACTIVITY; H3; METHYLATION; SACCHAROMYCES-CEREVISIAE; HETEROCHROMATIN DOMAIN; CHROMATIN-STRUCTURE; COMPLEX INCLUDES; GROUP PROTEINS; HP1; PROTEINS;

D O I：

10.2217/EPI.09.42

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Histone lysine methylation regulates a variety of nuclear processes including transcription and maintenance of genome integrity. Many attributes of the histone lysine methylation system suggest that it might also contribute to epigenetic memory. Here, we examine the recent advances in our understanding of three intensely-studied histone lysine methylation marks, focusing on the potential mechanisms by which these marks may be maintained during cell proliferation and adhere to the principles of epigenetics.

引用

页码：151 / 161

页数：11

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