Influences of bacterial extracellular vesicles on macrophage immune functions

被引:0
|
作者
Jiang, Bowei [1 ]
Huang, Junyun [2 ]
机构
[1] Gannan Med Univ, Sch Clin Med 1, Ganzhou, Peoples R China
[2] Gannan Med Univ, Affiliated Hosp 1, Dept Lab Med, Ganzhou, Peoples R China
关键词
extracellular vesicles; bacterial; macrophage; immune; influences; OUTER-MEMBRANE VESICLES; CELL; ACTIVATION; HOST; BIOGENESIS; MECHANISMS;
D O I
10.3389/fcimb.2024.1411196
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bacterial extracellular vesicles (EVs) are crucial mediators of information transfer between bacteria and host cells. Macrophages, as key effector cells in the innate immune system, have garnered widespread attention for their interactions with bacterial EVs. Increasing evidence indicates that bacterial EVs can be internalized by macrophages through multiple pathways, thereby influencing their immune functions. These functions include inflammatory responses, antimicrobial activity, antigen presentation, and programmed cell death. Therefore, this review summarizes current research on the interactions between bacterial EVs and macrophages. This will aid in the deeper understanding of immune modulation mediated by pathogenic microorganisms and provide a basis for developing novel antibacterial therapeutic strategies.
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页数:7
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