Hierarchical endpoints in critical care: A post-hoc exploratory analysis of the standard versus accelerated initiation of renal-replacement therapy in acute kidney injury and the intensity of continuous renal-replacement therapy in critically ill patients trials

被引：2
|
作者：
Zampieri, Fernando G. [1 ,2 ]
Serpa-Neto, Ary [3 ]
Wald, Ron [4 ,5 ]
Bellomo, Rinaldo [3 ,6 ,7 ,8 ,9 ,10 ,11 ]
Bagshaw, Sean M. [1 ,2 ]
机构：
[1] Univ Alberta, Fac Med & Dent, Dept Crit Care Med, Edmonton, AB, Canada
[2] Alberta Hlth Serv, Edmonton, AB, Canada
[3] Austin Hosp, Dept Intens Care, Melbourne, Australia
[4] Univ Toronto, St Michaels Hosp, Div Nephrol, 61 Queen St East, Toronto, ON, Canada
[5] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada
[6] Univ Tokyo Hosp, Dept Emergency & Crit Care Med, Tokyo, Japan
[7] Austin Hosp, Data Analyt Res & Evaluat DARE Ctr, Melbourne, Australia
[8] ANZICS Res Ctr, Melbourne, Australia
[9] Univ Melbourne, Dept Crit Care, Melbourne, Australia
[10] Royal Melbourne Hosp, Dept Intens Care, Melbourne, Australia
[11] Monash Univ, Sch & Publ Hlth & Prevent Med, Melbourne, Australia
来源：
JOURNAL OF CRITICAL CARE | 2024年 / 82卷
基金：
加拿大健康研究院; 英国医学研究理事会;
关键词：
Win ratio; Composite endpoint; Acute kidney injury; Renal replacement therapy; Sepsis; Intensive care unit; WIN RATIO;
D O I：
10.1016/j.jcrc.2024.154767
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Ary Serpa -Neto and sepsis. Selection of the endpoints and hierarchical ordering before trial design using the WR approach can have important implications for trial interpretation. Trial Registry : ClinicalTrials.gov number NCT02568722 (STARRT-AKI) and NCT00076219 (RENAL).
引用
收藏
页数：8
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