Hierarchical endpoints in critical care: A post-hoc exploratory analysis of the standard versus accelerated initiation of renal-replacement therapy in acute kidney injury and the intensity of continuous renal-replacement therapy in critically ill patients trials

被引：2

作者：

Zampieri, Fernando G. ^{[1
,2
]}

Serpa-Neto, Ary ^{[3
]}

Wald, Ron ^{[4
,5
]}

Bellomo, Rinaldo ^{[3
,6
,7
,8
,9
,10
,11
]}

Bagshaw, Sean M. ^{[1
,2
]}

机构：

[1] Univ Alberta, Fac Med & Dent, Dept Crit Care Med, Edmonton, AB, Canada

[2] Alberta Hlth Serv, Edmonton, AB, Canada

[3] Austin Hosp, Dept Intens Care, Melbourne, Australia

[4] Univ Toronto, St Michaels Hosp, Div Nephrol, 61 Queen St East, Toronto, ON, Canada

[5] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[6] Univ Tokyo Hosp, Dept Emergency & Crit Care Med, Tokyo, Japan

[7] Austin Hosp, Data Analyt Res & Evaluat DARE Ctr, Melbourne, Australia

[8] ANZICS Res Ctr, Melbourne, Australia

[9] Univ Melbourne, Dept Crit Care, Melbourne, Australia

[10] Royal Melbourne Hosp, Dept Intens Care, Melbourne, Australia

[11] Monash Univ, Sch & Publ Hlth & Prevent Med, Melbourne, Australia

来源：

JOURNAL OF CRITICAL CARE | 2024年 / 82卷

基金：

加拿大健康研究院; 英国医学研究理事会;

关键词：

Win ratio; Composite endpoint; Acute kidney injury; Renal replacement therapy; Sepsis; Intensive care unit; WIN RATIO;

D O I：

10.1016/j.jcrc.2024.154767

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Ary Serpa -Neto and sepsis. Selection of the endpoints and hierarchical ordering before trial design using the WR approach can have important implications for trial interpretation. Trial Registry : ClinicalTrials.gov number NCT02568722 (STARRT-AKI) and NCT00076219 (RENAL).

引用

页数：8

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