Robustness analysis of dynamic trajectory radiotherapy and volumetric modulated arc therapy plans for head and neck cancer

被引:4
|
作者
Loebner, Hannes A. [1 ,2 ,3 ]
Bertholet, Jenny [1 ,2 ,3 ]
Mackeprang, Paul-Henry [1 ,2 ,3 ]
Volken, Werner [1 ,2 ,3 ]
Elicin, Olgun [1 ,2 ,3 ]
Mueller, Silvan [1 ,2 ,3 ]
Guyer, Gian [1 ,2 ,3 ]
Aebersold, Daniel M. [1 ,2 ,3 ]
Stampanoni, Marco F. M. [2 ,4 ,5 ]
Fix, Michael K. [1 ,3 ]
Manser, Peter [1 ,2 ,3 ]
机构
[1] Bern Univ Hosp, Div Med Radiat Phys, Inselspital, Inselspital, Freiburgstrasse 18, CH-3010 Bern, Switzerland
[2] Bern Univ Hosp, Dept Radiat Oncol, Inselspital, Freiburgstrasse 18, Bern, Switzerland
[3] Univ Bern, Bern, Switzerland
[4] Swiss Fed Inst Technol, Inst Biomed Engn, Villigen, Switzerland
[5] PSI, Villigen, Switzerland
来源
PHYSICS & IMAGING IN RADIATION ONCOLOGY | 2024年 / 30卷
关键词
Head and neck cancer; Dynamic trajectory radiotherapy; VMAT; Robustness; Setup uncertainty; Machine uncertainty; SET-UP ERRORS; PLANNING MARGINS; UNCERTAINTIES; QUALITY; IMRT; VMAT; PERFORMANCE; SYSTEMS; ORGANS; RISK;
D O I
10.1016/j.phro.2024.100586
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and purpose: Dynamic trajectory radiotherapy (DTRT) has been shown to improve healthy tissue sparing compared to volumetric arc therapy (VMAT). This study aimed to assess and compare the robustness of DTRT and VMAT treatment-plans for head and neck (H &N) cancer to patient-setup (PS) and machine-positioning uncertainties. Materials and methods: The robustness of DTRT and VMAT plans previously created for 46 H &N cases, prescribed 50 - 70 Gy to 95 % of the planning-target-volume, was assessed. For this purpose, dose distributions were recalculated using Monte Carlo, including uncertainties in PS (translation and rotation) and machine-positioning (gantry-, table-, collimator-rotation and multi-leaf collimator (MLC)). Plan robustness was evaluated by the uncertainties ' impact on normal tissue complication probabilities (NTCP) for xerostomia and dysphagia and on dose-volume endpoints. Differences between DTRT and VMAT plan robustness were compared using Wilcoxon matched-pair signed-rank test ( alpha = 5 %). Results: Average NTCP for moderate-to-severe xerostomia and grade >= II dysphagia was lower for DTRT than VMAT in the nominal scenario (0.5 %, p = 0.01; 2.1 %, p < 0.01) and for all investigated uncertainties, except MLC positioning, where the difference was not significant. Average differences compared to the nominal scenario were <= 3.5 Gy for rotational PS (<= 3 degrees ) and machine-positioning (<= 2 degrees ) uncertainties, <7 Gy for translational PS uncertainties (<= 5 mm) and < 20 Gy for MLC-positioning uncertainties (<= 5 mm). Conclusions: DTRT and VMAT plan robustness to the investigated uncertainties depended on uncertainty direction and location of the structure-of-interest to the target. NTCP remained on average lower for DTRT than VMAT even when considering uncertainties.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Organ-at-risk sparing with dynamic trajectory radiotherapy for head and neck cancer: comparison with volumetric arc therapy on a publicly available library of cases
    Bertholet, Jenny
    Mackeprang, Paul-Henry
    Mueller, Silvan
    Guyer, Gian
    Loebner, Hannes A.
    Wyss, Yanick
    Frei, Daniel
    Volken, Werner
    Elicin, Olgun
    Aebersold, Daniel M.
    Fix, Michael K.
    Manser, Peter
    RADIATION ONCOLOGY, 2022, 17 (01)
  • [22] Dosimetric effect of body contour changes for prostate and head and neck volumetric modulated arc therapy plans
    Sun, Lingyue
    Kirkby, Charles
    Smith, Wendy
    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 2019, 20 (04): : 115 - 124
  • [23] Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry
    Vallard, Alexis
    Guy, Jean-Baptiste
    Ndong, Sylvie Mengue
    Vial, Nicolas
    Rivoirard, Romain
    Auberdiac, Pierre
    Mery, Benoite
    Langrand-Escure, Julien
    Espenel, Sophie
    Moncharmont, Coralie
    Ben Mrad, Majed
    Diao, Peng
    Goyet, Dominique
    Magne, Nicolas
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016, 38 (07): : 1028 - 1034
  • [24] Dosimetric impact of dental metallic crown on intensity-modulated radiotherapy and volumetric-modulated arc therapy for head and neck cancer
    Kamomae, Takeshi
    Itoh, Yoshiyuki
    Okudaira, Kuniyasu
    Nakaya, Takayoshi
    Tomida, Masashi
    Miyake, Yoshikazu
    Oguchi, Hiroshi
    Shiinoki, Takehiro
    Kawamura, Mariko
    Yamamoto, Noriyuki
    Naganawa, Shinji
    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS, 2016, 17 (01): : 234 - 245
  • [25] Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients
    Scorsetti, Marta
    Fogliata, Antonella
    Castiglioni, Simona
    Bressi, Caterina
    Bignardi, Mario
    Navarria, Piera
    Mancosu, Pietro
    Cozzi, Luca
    Pentimalli, Sara
    Alongi, Filippo
    Santoro, Armando
    RADIATION ONCOLOGY, 2010, 5
  • [26] Impact of shoulder deformation on volumetric modulated arc therapy doses for head and neck cancer
    Tachiban, Hidenobu
    Motegi, Kana
    Moriya, Shunsuke
    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2018, 53 : 118 - 128
  • [27] Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients
    Marta Scorsetti
    Antonella Fogliata
    Simona Castiglioni
    Caterina Bressi
    Mario Bignardi
    Piera Navarria
    Pietro Mancosu
    Luca Cozzi
    Sara Pentimalli
    Filippo Alongi
    Armando Santoro
    Radiation Oncology, 5
  • [28] Automatic interactive optimization for volumetric modulated arc therapy planning of head and neck cancer
    Tol, J.
    Dahele, M.
    Doornaert, P.
    Slotman, B. J.
    Verbakel, W. F. A. R.
    RADIOTHERAPY AND ONCOLOGY, 2015, 115 : S35 - S35
  • [29] Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer
    Ming, Xin
    Feng, Yuanming
    Liu, Huan
    Zhang, Ying
    Zhou, Li
    Deng, Jun
    PLOS ONE, 2015, 10 (12):
  • [30] Trajectory optimization for dynamic couch rotation during volumetric modulated arc radiotherapy
    Smyth, Gregory
    Bamber, Jeffrey C.
    Evans, Philip M.
    Bedford, James L.
    PHYSICS IN MEDICINE AND BIOLOGY, 2013, 58 (22): : 8163 - 8177