Ag-Catalyzed cross-dehydrogenative-coupling for the synthesis of 1,4-dioxan-2-yl substituted quinazoline hybrids in an aqueous medium

被引：0
|
作者：
Liu, Xixian [1 ]
Xie, Dayu [1 ]
Yang, Qin [1 ]
Song, Zhibin [1 ]
Fu, Yang [1 ]
Peng, Yiyuan [1 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Mat, Nanchang 330022, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 37期
基金：
中国国家自然科学基金;
关键词：
C-H FUNCTIONALIZATION; DIRECT ALPHA-ARYLATION; ETHERS; HETEROARENES; CHEMISTRY; ALPHA-C(SP(3))-H; 1H-INDAZOLES; QUINOLINE; ALCOHOLS;
D O I：
10.1039/d4ob01188k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We herein developed an effective approach for the construction of 2- or 4-(1,4-dioxan-2-yl) substituted quinazolines under mild conditions. A silver-K2S2O8 catalyzed direct CDC reaction between quinazolines and 1,4-dioxane for the synthesis of a series of 2- or 4-(1,4-dioxan-2-yl) substituted quinazoline hybrids is reported. The reaction proceeded well in water under mild conditions and showed a broad substrate scope and good functional group compatibility. An effective silver-K2S2O8 catalyzed CDC reaction between quinazolines and 1,4-dioxane for the construction of 2- or 4-(1,4-dioxan-2-yl) substituted quinazoline hybrids is described. The reaction proceeded well in water under mild conditions.
引用
收藏
页码：7725 / 7735
页数：11
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